A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors. - Wikidata - awgldk - TriplyDB

A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.

A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.

http://www.wikidata.org/entity/Q33601789

about

P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders.Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice.P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Molecular targets and mechanisms for ethanol action in glycine receptors Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteins Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells.Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor.Ethanol is a fast channel inhibitor of P2X4 receptors Implication of the purinergic system in alcohol use disorders.Activation and regulation of purinergic P2X receptor channels The basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol.Ivermectin reduces alcohol intake and preference in mice.Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) Rats Allosteric modulation of ATP-gated P2X receptor channels A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder.Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating.Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors.Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder.P2X4: A fast and sensitive purinergic receptor.Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders.Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.

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P2860

A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors.

http://www.wikidata.org/entity/Q33601789

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

A point mutation in the ectodo ...... of ethanol in P2X4 receptors.

@ast

A point mutation in the ectodo ...... of ethanol in P2X4 receptors.

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type

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A point mutation in the ectodo ...... of ethanol in P2X4 receptors.

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A point mutation in the ectodo ...... of ethanol in P2X4 receptors.

@en

prefLabel

A point mutation in the ectodo ...... of ethanol in P2X4 receptors.

@ast

A point mutation in the ectodo ...... of ethanol in P2X4 receptors.

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J.1471-4159.2009.06460.X

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Journal of Neurochemistry

P1476

A point mutation in the ectodo ...... of ethanol in P2X4 receptors.

@en

P2093

Kaixun Li

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Liana Asatryan

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Maya Popova

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Olga Ostrovskaya

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Ronald L Alkana

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P2860

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

A simple method for displaying the hydropathic character of a protein

Hetero-oligomeric assembly of P2X receptor subunits. Specificities exist with regard to possible partners

Mortality and morbidity attributable to use of addictive substances in the United States

Molecular physiology of P2X receptors

P2X receptors and nociception

Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems

Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism

Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures

Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice

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307-317

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10.1111/J.1471-4159.2009.06460.X

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Daryl L. Davies

Letisha R Wyatt

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2009-10-28T00:00:00Z

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