Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice - Wikidata - awgldk - TriplyDB

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice

http://www.wikidata.org/entity/Q36025303

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ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst Chemokines, selectins and intracellular calcium flux: temporal and spatial cues for leukocyte arrest Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection Neutrophil cell surface receptors and their intracellular signal transduction pathways.Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.Video-rate two-photon imaging of mouse footpad - a promising model for studying leukocyte recruitment dynamics during inflammation.Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells.Osteopetrosis with micro-lacunar resorption because of defective integrin organization NOX2-dependent regulation of inflammation Lipid signaling in T-cell development and function ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling.Vav/Phospholipase Cgamma2-mediated control of a neutrophil-dependent murine model of rheumatoid arthritis.Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation.Sinomenine protects against lipopolysaccharide-induced acute lung injury in mice via adenosine A(2A) receptor signaling.CD8+ T cells regulate bone tumor burden independent of osteoclast resorption.Vav protein guanine nucleotide exchange factor regulates CD36 protein-mediated macrophage foam cell formation via calcium and dynamin-dependent processes.Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1 Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines.Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.Phospholipase Cγ2 is required for basal but not oestrogen deficiency-induced bone resorption.Role of phospholipase Cε in physiological phosphoinositide signaling networks.Regulation of innate immunity by NADPH oxidase.Deciphering mechanisms of staphylococcal biofilm evasion of host immunity.Immune complexes isolated from patients with pulmonary tuberculosis modulate the activation and function of normal granulocytes NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury.The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12 Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.The ins and outs of leukocyte integrin signaling.Are reactive oxygen species always detrimental to pathogens?Sialic acids siglec interaction: a unique strategy to circumvent innate immune response by pathogens.Roles of phospholipase C isozymes in organogenesis and embryonic development.Physiological and pathophysiological functions of SOCE in the immune system.

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P2860

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice

http://www.wikidata.org/entity/Q36025303

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Neutrophil-mediated oxidative ...... Cgamma2 signaling axis in mice

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Neutrophil-mediated oxidative ...... Cgamma2 signaling axis in mice

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Journal of Clinical Investigation

P1476

Neutrophil-mediated oxidative ...... Cgamma2 signaling axis in mice

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P2093

Charles M Robertson

http://www.w3.org/2001/XMLSchema#string

Craig M Coopersmith

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Daniel B Graham

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Francesca Mascarenhas

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M Julia Diacovo

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Roberta Faccio

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Siu Kit Lam

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Viviana Cremasco

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Vivianne Montgrain

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W Michael Dunne

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P2860

Chronic Granulomatous Disease; fundamental stages in our understanding of CGD

Guidelines for the Management of Adults with Hospital-acquired, Ventilator-associated, and Healthcare-associated Pneumonia

PRAM-1 is required for optimal integrin-dependent neutrophil function

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils.

Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.

P304

3445-3452

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10.1172/JCI32729

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11

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P478

117

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Jhoanne Bautista

P577

2007-11-01T00:00:00Z

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5911819

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17932569

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2000813

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