Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene - Wikidata - awgldk - TriplyDB

Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene

Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene

http://www.wikidata.org/entity/Q36042066

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MIA is a potential biomarker for tumour load in neurofibromatosis type 1 NMF-mGPU: non-negative matrix factorization on multi-GPU systems Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.Monozygotic twins with Neurofibromatosis type 1, concordant phenotype and synchronous development of MPNST and metastasis.MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1.In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1.Epidemiology and therapies for metastatic sarcoma Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors.Analysis of steroid hormone effects on xenografted human NF1 tumor schwann cells Survivin expression and prognostic significance in pediatric malignant peripheral nerve sheath tumors (MPNST).The versatile functions of Sox9 in development, stem cells, and human diseases Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2 Genetically engineered mouse models shed new light on the pathogenesis of neurofibromatosis type I-related neoplasms of the peripheral nervous system.Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine.Nerve Sheath Tumors in Neurofibromatosis Type 1: Assessment of Whole-Body Metabolic Tumor Burden Using F-18-FDG PET/CT.Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve.Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis Runx1 contributes to neurofibromatosis type 1 neurofibroma formation.Gene signature associated with benign neurofibroma transformation to malignant peripheral nerve sheath tumors MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cells Role of LRF/Pokemon in lineage fate decisions.Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors.EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors.CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems The SOX family of genes in cancer development: biological relevance and opportunities for therapy.Neurofibromatosis type 1: diagnosis and recent advances.Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.Telomere erosion in NF1 tumorigenesis.Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours.The primacy of NF1 loss as the driver of tumorigenesis in neurofibromatosis type 1-associated plexiform neurofibromas.Neurofibromatosis and lessons for the war on cancer.Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.

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Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene

http://www.wikidata.org/entity/Q36042066

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Integrative genomic analyses o ...... a biomarker and survival gene

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EMBO Molecular Medicine

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Integrative genomic analyses o ...... a biomarker and survival gene

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Anat Stemmer-Rachamimov

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Atira Hardiman

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Conxi Lazaro

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Hua Li

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P2860

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data.

Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis

The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

Tumor microenvironment and neurofibromatosis type I: connecting the GAPs

Malignant peripheral nerve sheath tumours in neurofibromatosis 1

The PowerAtlas: a power and sample size atlas for microarray experimental design and research.

A proposed metric for assessing the measurement quality of individual microarrays.

Exploration, normalization, and summaries of high density oligonucleotide array probe level data

NF1 gene and neurofibromatosis 1

NF1 tumor suppressor gene function: narrowing the GAP

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10.1002/EMMM.200900027

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