Adaptive mitochondrial reprogramming and resistance to PI3K therapy. - Wikidata - awgldk - TriplyDB

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

http://www.wikidata.org/entity/Q36047440

about

Metabolomics: Bridging the Gap between Pharmaceutical Development and Population Health Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion.Global transcriptomic analysis of induced cardiomyocytes predicts novel regulators for direct cardiac reprogramming.Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma.The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.Disabling mitochondrial reprogramming in cancer Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy.Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.Akt targeting as a strategy to boost chemotherapy efficacy in non-small cell lung cancer through metabolism suppression.Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma.Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS.Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.TUSC2 downregulates PD-L1 expression in non-small cell lung cancer (NSCLC).Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer.Impaired pentose phosphate pathway in the development of 3D MCF-7 cells mediated intracellular redox disturbance and multi-cellular resistance without drug induction.Drug repurposing for the treatment of glioblastoma multiforme.The relevance of tyrosine kinase inhibitors for global metabolic pathways in cancer.Mitochondria and Cancer.Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma.β-Adrenergic receptor modulates mitochondrial metabolism and disease progression in recurrent/metastatic HPV(+) HNSCC Mitochondrial metabolism and cancer

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P2860

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

http://www.wikidata.org/entity/Q36047440

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

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Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

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type

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Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

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Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

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prefLabel

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

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Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

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Journal of the National Cancer Institute

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Adaptive mitochondrial reprogramming and resistance to PI3K therapy

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Andrew V Kossenkov

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Dario C Altieri

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David C Schultz

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Jae Ho Seo

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Jagadish C Ghosh

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Markus D Siegelin

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Massimo Giroda

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Michele Tavecchio

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Paolo Rampini

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Ryan D Michalek

http://www.w3.org/2001/XMLSchema#string

P2860

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

Understanding the Warburg effect: the metabolic requirements of cell proliferation

AKT/PKB signaling: navigating downstream

Evolution of the cancer genome

Cancer invasion and the microenvironment: plasticity and reciprocity

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Adapting proteostasis for disease intervention

Defining the role of mTOR in cancer

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

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scholarly article

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10.1093/JNCI/DJU502

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3

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107

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Alice Faversani

Valentina Vaira

Lucia R. Languino

M Cecilia Caino

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2015-02-03T00:00:00Z

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272075486

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25650317

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4565533

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