Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.
about
Human INT6/eIF3e is required for nonsense-mediated mRNA decaySMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decayThe surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsCloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinA 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus.SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeastA mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindredsMechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exonA nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decayMolecular basis of maple syrup urine disease: novel mutations at the E1 alpha locus that impair E1(alpha 2 beta 2) assembly or decrease steady-state E1 alpha mRNA levels of branched-chain alpha-keto acid dehydrogenase complexIdentification of three novel mutations in non-Ashkenazi Italian patients with muscle phosphofructokinase deficiencyThe molecular basis of HEXA mRNA deficiency caused by the most common Tay-Sachs disease mutationPosttranscriptional control of gene expression in yeast.Yeast Upf1 CH domain interacts with Rps26 of the 40S ribosomal subunit.The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm.Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorymRNA stability in mammalian cellsFrameshift mutations in the v-src gene of avian sarcoma virus act in cis to specifically reduce v-src mRNA levels.Heat sensitivity in a bentgrass variant. Failure to accumulate a chloroplast heat shock protein isoform implicated in heat tolerance.Modulation of nonsense mediated decay by rapamycinmRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?Correction of genetic disease by making sense from nonsense.Intranuclear degradation of nonsense codon-containing mRNAInitiation of protein synthesis in mammalian cells with codons other than AUG and amino acids other than methionine.At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation.Identification of an additional gene required for eukaryotic nonsense mRNA turnover.A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent mannerNonsense-mediated decay of human HEXA mRNA.Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability.Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing.Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.Cis-acting elements are required for selenium regulation of glutathione peroxidase-1 mRNA levels.Mature mRNAs accumulated in the nucleus are neither the molecules in transit to the cytoplasm nor constitute a stockpile for gene expression.Under the Tucson sun: a meeting in the desert on mRNA decay.5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.mRNA transport in yeast: time to reinvestigate the functions of the nucleolus.Killing the messenger: new insights into nonsense-mediated mRNA decay.When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.Independent overexpression of the subunits of translation elongation factor complex eEF1H in human lung cancer.Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?
P2860
Q24304228-809A96FC-6CD9-4755-A538-656D1651A212Q24322423-2809C83C-7624-4C89-BEA4-533FB13F6D04Q24324097-434D08E2-515A-461F-918D-733703F692C1Q24336236-D4138A82-A8EA-4682-84EC-0FC5306E29B6Q24537503-6D1EBA14-9EF2-46AD-9A5D-B932CED22DA9Q24554452-C1B93790-5B0F-4876-A3D5-928FD8301E3DQ24605337-6E3001D4-37EE-4F92-BCCC-6FD62653BCE6Q24613209-25CA0318-EAE0-4ACD-8BC3-AED7B5D3875BQ24633921-7C3B619D-D0CB-4943-B291-7A209649A91BQ24672679-89807E3C-67AA-4011-B3B1-EB29220A9D01Q24672931-7659EAC4-29A2-47FE-BFEC-885195561613Q24673000-ED527E5D-8EA6-430F-984E-AFE25AA2E715Q27937074-851D60C9-71CE-46D0-9E81-6F6C794CA773Q27938110-A55FBD3B-929A-47B1-8310-D84995D02B60Q27938663-85A7931C-6586-4F2F-BA61-4ABF5EE33753Q28082699-F20B5FAB-DAD2-456A-AB20-B38A8121C419Q29616374-5E19E532-4693-4D73-B1CA-E0D502984BEDQ30450229-FA39F7A8-6E30-4BB1-9E88-E8BE32BEE6E6Q33188510-C207770E-9359-4812-BEB0-76D8DFF46E6BQ33557383-502FCA6F-B1F1-417E-8F87-8B7E3008CEFFQ33665734-4E827372-AA54-474A-BD27-75E5D635C408Q33712661-F1F631DA-21AA-46CC-A7A7-8DC0B22072D2Q33758035-8387C68D-1E6C-480E-83F9-99F90386DCF5Q33777524-75BBBD16-3639-4A45-896E-83E98B6B7F57Q33778146-E4C26349-DF99-4A50-9656-F0C5E5C925B8Q33837730-7EB4D3E0-C979-49BF-96F1-7EFC9F807F44Q33957345-20FFB958-B6D4-4555-A104-7FAB336A3B05Q33969215-D6C6F20D-4251-426E-851C-EBF96F0CC8D6Q34291581-8BEF9D78-2666-4EB4-98BD-78C5FE5A0031Q34361052-2D9276F0-72D6-4CFB-A47B-EE2AD473C03AQ34361461-EB603DF0-641E-4317-9B62-F41A3B4B8D75Q34361471-EF24A43C-96A1-4E8C-8BAF-87BC0E66736EQ34362798-66A8B017-ADA3-450B-A339-83D9EF38C69BQ34366114-F7936D50-5065-4207-B3D2-FE0564804970Q34443734-63D97061-D86E-4D77-A6D8-BD51D6B976F4Q34447643-4790AB45-BEA5-4C6C-AA19-DA8C6271FB6CQ34487265-19F06E72-4EFB-4F6D-9134-3FF0A9A65E10Q34693550-19C2C284-AB88-42C7-BE7B-8644343904C9Q34695733-D25942C2-05BE-44DD-B0A1-040FD4D17C7EQ34736844-935CEF67-BFB8-40E6-9B4A-1CE8794E441B
P2860
Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Evidence to implicate translat ...... riosephosphate isomerase mRNA.
@ast
Evidence to implicate translat ...... riosephosphate isomerase mRNA.
@en
type
label
Evidence to implicate translat ...... riosephosphate isomerase mRNA.
@ast
Evidence to implicate translat ...... riosephosphate isomerase mRNA.
@en
prefLabel
Evidence to implicate translat ...... riosephosphate isomerase mRNA.
@ast
Evidence to implicate translat ...... riosephosphate isomerase mRNA.
@en
P2093
P2860
P356
P1476
Evidence to implicate translat ...... riosephosphate isomerase mRNA.
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.2.482
P407
P577
1993-01-01T00:00:00Z