TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia
about
Is TMC1 the Hair Cell Mechanotransducer Channel?Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.Recessive mutations of TMC1 associated with moderate to severe hearing loss.RNA Interference Prevents Autosomal-Dominant Hearing Loss.Development and localization of reverse-polarity mechanotransducer channels in cochlear hair cellsMolecular Identity of the Mechanotransduction Channel in Hair Cells: Not Quiet There Yet.Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells.Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology.Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors.MyTH4-FERM myosins in the assembly and maintenance of actin-based protrusions.Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function.Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation.Emerging Gene Therapies for Genetic Hearing Loss.d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity.Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells.Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation.Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus).TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells.A molecular basis for water motion detection by the mechanosensory lateral line of zebrafish.Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance.Mechanically Gated Ion Channels in Mammalian Hair Cells.Variable number of TMC1-dependent mechanotransducer channels underlie tonotopic conductance gradients in the cochlea.Using Drosophila to study mechanisms of hereditary hearing loss.Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteinsTransgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function
P2860
Q26740537-E7703F54-E2BA-424B-8A17-22BD06C5099FQ30354585-6688F0A7-0845-49E1-A4A6-57F1C2A033E5Q30354602-0356414F-3867-40C7-9986-B9FBEF344D30Q30833261-D9FA0D23-9CAD-4A0E-8787-469D712F3159Q33854359-42CD2A90-6073-4861-ADC7-B3509129B1C5Q36698106-8532013B-0B5F-495A-B774-520A38E94CE3Q37004981-BC4D0B1B-6656-452E-B01C-7BF9A014D65DQ37021850-63E5D740-85BB-4C98-985C-E7734D06979CQ37398454-2E42EDD1-FBD8-4725-82B0-23B6AE2577E8Q38549121-48DF555C-BF8B-4EEA-B1CE-CB426A1F2DE4Q38646692-CAC26D03-6E1A-4CC6-AFA3-27911ADADF60Q39004700-D514AC9F-DF73-4430-9906-DBDC9FD6DB4AQ39005661-464DF8D1-49A2-4E14-B3C5-EA7107DB6F46Q39015106-5B8FDE9F-DDCB-4C10-A2EA-345324962F97Q39968477-C247CECF-DAC7-488E-B163-E5A4EE7C5030Q40080564-52C70963-7EFE-4123-BCB3-97F961F0AE2AQ41454597-35C609A5-7F3D-4B1E-8085-3169B2393C45Q42108681-3A7E874F-323C-4580-BE0B-3A08A7AEA53BQ42372905-8A4CF8CB-DBB1-40C0-9EF3-BFEB58B85DD7Q42618413-2862CBE4-DD02-4DAB-972B-CA326979E463Q42698907-449DD2F8-60A8-4585-A049-B1A4B03ABE3DQ44492142-8F5B7990-4B4A-4986-84A2-D679A74E60ADQ45797937-D6A34DE2-8B57-4C3D-B0B7-4454996E90D0Q47147651-6779866F-7D14-42BD-A172-E75E4314EF3AQ47894540-DF3B4C4E-8C33-46BE-8FCA-1BFFFC483766Q53821964-A76FE522-E097-4977-B649-0A08482C67ACQ55384992-AFB3DC33-9DAC-42A6-8230-33B1D5EE8179Q55519023-531F5D7E-CAB3-439E-8B00-4D76AF4A8490Q56530849-FD1D19C1-97D7-4BBB-9AF4-B787605C326EQ58782804-C631E198-F39C-43C1-B243-86E5FB5D9906Q58783095-B97333B2-C705-47FD-92AA-BD174167FD11
P2860
TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
TMC1 and TMC2 Localize at the ...... nner Ear Hair Cell Stereocilia
@ast
TMC1 and TMC2 Localize at the ...... nner Ear Hair Cell Stereocilia
@en
type
label
TMC1 and TMC2 Localize at the ...... nner Ear Hair Cell Stereocilia
@ast
TMC1 and TMC2 Localize at the ...... nner Ear Hair Cell Stereocilia
@en
prefLabel
TMC1 and TMC2 Localize at the ...... nner Ear Hair Cell Stereocilia
@ast
TMC1 and TMC2 Localize at the ...... nner Ear Hair Cell Stereocilia
@en
P2093
P2860
P1433
P1476
TMC1 and TMC2 Localize at the ...... nner Ear Hair Cell Stereocilia
@en
P2093
Andrew J Griffith
Bechara Kachar
Bifeng Pan
Bryan A Millis
Byung Yoon Choi
Hiroshi Nakanishi
Jeffrey R Holt
Kelly Monahan
Kiyoto Kurima
Miloslav Sedlacek
P2860
P304
P356
10.1016/J.CELREP.2015.07.058
P577
2015-08-28T00:00:00Z