Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10
about
Neurogenomics of speech and language disorders: the road aheadRecurrent SETBP1 mutations in atypical chronic myeloid leukemiaThe molecular basis of myeloid malignancies.SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies.Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia developmentAn International MDS/MPN Working Group's perspective and recommendations on molecular pathogenesis, diagnosis and clinical characterization of myelodysplastic/myeloproliferative neoplasms.Recurrent deletions of IKZF1 in pediatric acute myeloid leukemiaSomatic SETBP1 mutations in myeloid malignanciesBRCC3 mutations in myeloid neoplasms.Myb expression is critical for myeloid leukemia development induced by Setbp1 activation.Targeting chronic myeloid leukemia stem cells.Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable.Cellular and Molecular Networks in Chronic Myeloid Leukemia: The Leukemic Stem, Progenitor and Stromal Cell Interplay.Somatic SETBP1 mutations in myeloid neoplasms.A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia.Mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia: a report from the Italian AIEOP study group.SETBP1 mutations in 415 patients with primary myelofibrosis or chronic myelomonocytic leukemia: independent prognostic impact in CMML.Severe congenital neutropenia and chronic neutrophilic leukemia: an intriguing molecular connection unveiled by oncogenic mutations in CSF3R.A new player SETs in myeloid malignancy.SETBP1 mutations occur in 9% of MDS/MPN and in 4% of MPN cases and are strongly associated with atypical CML, monosomy 7, isochromosome i(17)(q10), ASXL1 and CBL mutations.SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias.Hoxa9 and Hoxa10 induce CML myeloid blast crisis development through activation of Myb expression.Only SETBP1 hotspot mutations are associated with refractory disease in myeloid malignancies.Methylation of the HOXA10 promoter directs miR-196b-5p dependent cell proliferation and invasion of gastric cancer cells.Granulocyte colony-stimulating factor receptor T595I (T618I) mutation confers ligand independence and enhanced signaling.SETBP1 mutation analysis in 944 patients with MDS and AML.SETBP1 mutations in juvenile myelomonocytic leukaemia and myelodysplastic syndrome but not in paediatric acute myeloid leukaemia.SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub.ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation
P2860
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P2860
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Setbp1 promotes the self-renew ...... activation of Hoxa9 and Hoxa10
@ast
Setbp1 promotes the self-renew ...... activation of Hoxa9 and Hoxa10
@en
type
label
Setbp1 promotes the self-renew ...... activation of Hoxa9 and Hoxa10
@ast
Setbp1 promotes the self-renew ...... activation of Hoxa9 and Hoxa10
@en
prefLabel
Setbp1 promotes the self-renew ...... activation of Hoxa9 and Hoxa10
@ast
Setbp1 promotes the self-renew ...... activation of Hoxa9 and Hoxa10
@en
P2093
P2860
P1433
P1476
Setbp1 promotes the self-renew ...... activation of Hoxa9 and Hoxa10
@en
P2093
Bandana A Vishwakarma
Jonathan Keller
Kevin Oakley
Kristbjorn O Gudmundsson
Ravi Bhatia
Vasyl Vasko
Xiongfong Chen
P2860
P304
P356
10.1182/BLOOD-2011-10-388710
P407
P577
2012-05-07T00:00:00Z