Granulocyte colony-stimulating factor receptor T595I (T618I) mutation confers ligand independence and enhanced signaling.
about
G-CSF and GM-CSF in NeutropeniaClinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia.The Colony-Stimulating Factor 3 Receptor T640N Mutation Is Oncogenic, Sensitive to JAK Inhibition, and Mimics T618I.Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization.Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy.Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies.Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition.Characterization of the leukemogenic potential of distal cytoplasmic CSF3R truncation and missense mutations.Severe congenital neutropenia and chronic neutrophilic leukemia: an intriguing molecular connection unveiled by oncogenic mutations in CSF3R.Gain-of-function mutations in granulocyte colony-stimulating factor receptor (CSF3R) reveal distinct mechanisms of CSF3R activation.
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Granulocyte colony-stimulating factor receptor T595I (T618I) mutation confers ligand independence and enhanced signaling.
description
2013 nî lūn-bûn
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name
Granulocyte colony-stimulating ...... ndence and enhanced signaling.
@en
Granulocyte colony-stimulating factor receptor T595I
@nl
type
label
Granulocyte colony-stimulating ...... ndence and enhanced signaling.
@en
Granulocyte colony-stimulating factor receptor T595I
@nl
prefLabel
Granulocyte colony-stimulating ...... ndence and enhanced signaling.
@en
Granulocyte colony-stimulating factor receptor T595I
@nl
P2093
P2860
P356
P1433
P1476
Granulocyte colony-stimulating ...... ndence and enhanced signaling.
@en
P2093
B Przychodzen
H Makishima
J Maciejewski
M A McDevitt
N C P Cross
T Glaubach
P2860
P2888
P304
P356
10.1038/LEU.2013.164
P577
2013-06-06T00:00:00Z