Impact of N-terminal acetylation of α-synuclein on its random coil and lipid binding properties
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α-Synuclein as an intrinsically disordered monomer--fact or artefact?Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation ratesProperties of native brain α-synucleinNative α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Biophysical characterization of α-synuclein and its controversial structureExploring the accessible conformations of N-terminal acetylated α-synucleinNMR Structure of Calmodulin Complexed to an N-Terminally Acetylated α-Synuclein PeptideThe Synaptic Function of α-SynucleinSynthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational ModificationsMechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescenceIn-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cellsThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseIs Transthyretin a Regulator of Ubc9 SUMOylation?Impact of hydrostatic pressure on an intrinsically disordered protein: a high-pressure NMR study of α-synucleinA natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicityMERA: a webserver for evaluating backbone torsion angle distributions in dynamic and disordered proteins from NMR data.Accurate measurement of (3)J(HNHα) couplings in small or disordered proteins from WATERGATE-optimized TROSY spectra.The C-terminal threonine of Aβ43 nucleates toxic aggregation via structural and dynamical changes in monomers and protofibrils.Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model.Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.Conformational heterogeneity of α-synuclein in membrane.A maximum entropy approach to the study of residue-specific backbone angle distributions in α-synuclein, an intrinsically disordered protein.Alpha-synuclein function and dysfunction on cellular membranes.Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour.N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.Quantitative evaluation of positive ϕ angle propensity in flexible regions of proteins from three-bond J couplingsThe Interplay between Alpha-Synuclein Clearance and SpreadingDeuterium isotope shifts for backbone ¹H, ¹⁵N and ¹³C nuclei in intrinsically disordered protein α-synucleinThe influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein.Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sitesMonomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil.Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy.Dimer interface of bovine cytochrome c oxidase is influenced by local posttranslational modifications and lipid binding.Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains.Structural basis of synaptic vesicle assembly promoted by α-synuclein.Membrane remodeling by α-synuclein and effects on amyloid formation.N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes.Evidence of native α-synuclein conformers in the human brain.Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.
P2860
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P2860
Impact of N-terminal acetylation of α-synuclein on its random coil and lipid binding properties
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Impact of N-terminal acetylati ...... l and lipid binding properties
@ast
Impact of N-terminal acetylati ...... l and lipid binding properties
@en
type
label
Impact of N-terminal acetylati ...... l and lipid binding properties
@ast
Impact of N-terminal acetylati ...... l and lipid binding properties
@en
prefLabel
Impact of N-terminal acetylati ...... l and lipid binding properties
@ast
Impact of N-terminal acetylati ...... l and lipid binding properties
@en
P2093
P2860
P356
P1433
P1476
Impact of N-terminal acetylati ...... l and lipid binding properties
@en
P2093
Alexander S Maltsev
Jinfa Ying
P2860
P304
P356
10.1021/BI300642H
P407
P577
2012-06-14T00:00:00Z