Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.
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Neurodegeneration with brain iron accumulation: update on pathogenic mechanismsEmerging preclinical pharmacological targets for Parkinson's diseaseGenetic association of RIT2 rs12456492 polymorphism and Parkinson's disease susceptibility in Asian populations: a meta-analysisAutophagy and neurodegenerationCellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disordersGenetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type CLysosome and calcium dysregulation in Alzheimer's disease: partners in crimeParkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceAutophagosome dynamics in neurodegeneration at a glanceA lipid switch unlocks Parkinson's disease-associated ATP13A2Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulationATP13A2 and Alpha-synuclein: a Metal Taste in AutophagyATP13A2/PARK9 regulates secretion of exosomes and α-synucleinATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neuronsAutophagy in Neurodegenerative Diseases and Metal NeurotoxicityDopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's diseaseLIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearanceAtp13a2 expression in the periaqueductal gray is decreased in the Pink1 -/- rat model of Parkinson disease.Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunctionDeregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorderATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodiesLysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Mutations in the ATP13A2 gene and Parkinsonism: a preliminary review.The pallidopyramidal syndromes: nosology, aetiology and pathogenesis.Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells.Analysis of Thr12Met and Ala1144Thr mutations of the ATP13A2 gene in Parkinson's disease patients in Xinjiang Uygur and Han ethnic groups.α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases.Identification of Cerebral Metal Ion Imbalance in the Brain of Aging Octodon degus.Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits.Review: Insights into molecular mechanisms of disease in neurodegeneration with brain iron accumulation: unifying theories.TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicityOptogenetic acidification of synaptic vesicles and lysosomes.Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidificationA somatic cell defect is associated with the onset of neurological symptoms in a lysosomal storage disease.Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy.Lysosomal impairment in Parkinson's disease.
P2860
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P2860
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Loss of P-type ATPase ATP13A2/ ...... son disease neurodegeneration.
@ast
Loss of P-type ATPase ATP13A2/ ...... son disease neurodegeneration.
@en
type
label
Loss of P-type ATPase ATP13A2/ ...... son disease neurodegeneration.
@ast
Loss of P-type ATPase ATP13A2/ ...... son disease neurodegeneration.
@en
prefLabel
Loss of P-type ATPase ATP13A2/ ...... son disease neurodegeneration.
@ast
Loss of P-type ATPase ATP13A2/ ...... son disease neurodegeneration.
@en
P2093
P2860
P50
P356
P1476
Loss of P-type ATPase ATP13A2/ ...... nson disease neurodegeneration
@en
P2093
Anne Vital
Celine Perier
Christine Klein
P2860
P304
P356
10.1073/PNAS.1112368109
P407
P50
P577
2012-05-30T00:00:00Z