Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification - Wikidata - awgldk - TriplyDB

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

http://www.wikidata.org/entity/Q36960882

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The crucial impact of lysosomes in aging and longevity New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime Single-walled carbon nanotubes alleviate autophagic/lysosomal defects in primary glia from a mouse model of Alzheimer's disease Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms Autophagy upregulates (Pro)renin receptor expression via reduction of P62/SQSTM1 and activation of ERK1/2 signaling pathway in podocytes.Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models.Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice Energy restriction and potential energy restriction mimetics.Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease.The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease.Alteration of lysosome fusion and low-grade inflammation mediated by super-low-dose endotoxin.A neuronal aging pattern unique to humans and common chimpanzees.Manipulating autophagic processes in autoimmune diseases: a special focus on modulating chaperone-mediated autophagy, an emerging therapeutic target.The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease.Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex.Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.Autophagy involving age-related cognitive behavior and hippocampus injury is modulated by different caloric intake in mice.Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.High ω3-polyunsaturated fatty acids in fat-1 mice prevent streptozotocin-induced Purkinje cell degeneration through BDNF-mediated autophagy Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress.Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal.Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimer's disease mice.Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease.Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease.Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation.The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments The effect of the top 20 Alzheimer disease risk genes on gray-matter density and FDG PET brain metabolism.Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.Autophagic/lysosomal dysfunction in Alzheimer's disease.

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Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

http://www.wikidata.org/entity/Q36960882

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2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Autophagy failure in Alzheimer ...... ective lysosomal acidification

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type

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Autophagy failure in Alzheimer ...... ective lysosomal acidification

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Autophagy failure in Alzheimer ...... ective lysosomal acidification

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Autophagy failure in Alzheimer ...... ective lysosomal acidification

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P2093

Asok Kumar

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Devin M Wolfe

http://www.w3.org/2001/XMLSchema#string

Ju-Hyun Lee

http://www.w3.org/2001/XMLSchema#string

Ralph A Nixon

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Samantha J Orenstein

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Sooyeon Lee

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P2860

Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs)

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

Autophagy in the Pathogenesis of Disease

Autophagy fights disease through cellular self-digestion

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

Structure and chromosomal assignment of the human cathepsin K gene

The roles of intracellular protein-degradation pathways in neurodegeneration

Disassembly and reassembly of the yeast vacuolar H(+)-ATPase in vivo

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

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10.1111/EJN.12169

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12

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37

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23773064

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Alzheimer's disease

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3694736

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