The role of human carboxylesterases in drug metabolism: have we overlooked their importance?
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Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin modelsPharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme InhibitorsDatabase of Optimized Proteomic Quantitative Methods for Human Drug Disposition-Related Proteins for Applications in Physiologically Based Pharmacokinetic Modeling.Identification of alcohol-dependent clopidogrel metabolites using conventional liquid chromatography/triple quadrupole mass spectrometryThe hepatocyte proteome in organotypic rat liver models and the influence of the local microenvironment.In vitro metabolism and drug-drug interaction potential of UTL-5g, a novel chemo- and radioprotective agent.Identification of potent inhibitors of the chicken soluble epoxide hydrolase.Tartaric acid-based amphiphilic macromolecules with ether linkages exhibit enhanced repression of oxidized low density lipoprotein uptake.Effects of alcohol on human carboxylesterase drug metabolism.A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme inhibitors.Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer DiseaseSacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation.A novel prodrug strategy to improve the oral absorption of O-desmethylvenlafaxine.Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis.Association between statin use and ischemic stroke or major hemorrhage in patients taking dabigatran for atrial fibrillationEffects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers.Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry.Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism.Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG.Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension.Suppression of carboxylesterases by imatinib mediated by the down-regulation of pregnane X receptor.Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions.Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.Carboxylesterases in lipid metabolism: from mouse to human.Multicolor imaging of endoplasmic reticulum-located esterase as a prodrug activation enzyme.Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors.Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny.Alteration of Multiple Leukocyte Gene Expression Networks is Linked with Magnetic Resonance Markers of Prognosis After Acute ST-Elevation Myocardial Infarction.Constitutive expression of a fungus-inducible carboxylesterase improves disease resistance in transgenic pepper plants.Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms.Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients.Human carboxylesterase 2: Studies on the role of glycosylation for enzymatic activity.Optimization of antitumor modulators of pre-mRNA splicing.Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate.Hydrolysis, polarity, and conformational impact of C-terminal partially fluorinated ethyl esters in peptide models.Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots following Directly Observed Therapy: the DOT-DBS Study.New Insights into the Microbiota of Moth Pests.Ultrasmall and photostable nanotheranostic agents based on carbon quantum dots passivated with polyamine-containing organosilane molecules.
P2860
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P2860
The role of human carboxylesterases in drug metabolism: have we overlooked their importance?
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The role of human carboxyleste ...... e overlooked their importance?
@ast
The role of human carboxyleste ...... e overlooked their importance?
@en
type
label
The role of human carboxyleste ...... e overlooked their importance?
@ast
The role of human carboxyleste ...... e overlooked their importance?
@en
prefLabel
The role of human carboxyleste ...... e overlooked their importance?
@ast
The role of human carboxyleste ...... e overlooked their importance?
@en
P2093
P2860
P356
P1433
P1476
The role of human carboxyleste ...... e overlooked their importance?
@en
P2093
Kevin Witbrodt
Robert B Parker
S Casey Laizure
Vanessa Herring
P2860
P304
P356
10.1002/PHAR.1194
P407
P577
2013-02-01T00:00:00Z