Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol
about
Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics.Metabolic activation of clopidogrel: in vitro data provide conflicting evidence for the contributions of CYP2C19 and PON1The effect of ethanol on oral cocaine pharmacokinetics reveals an unrecognized class of ethanol-mediated drug interactions.Identification of alcohol-dependent clopidogrel metabolites using conventional liquid chromatography/triple quadrupole mass spectrometryStructure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs.Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation.Surge in expression of carboxylesterase 1 during the post-neonatal stage enables a rapid gain of the capacity to activate the anti-influenza prodrug oseltamivir.Transdermal and oral dl-methylphenidate-ethanol interactions in C57BL/6J mice: transesterification to ethylphenidate and elevation of d-methylphenidate concentrationsEffects of alcohol on human carboxylesterase drug metabolism.Effect of grapefruit juice on the bioactivation of prasugrelThe role of human carboxylesterases in drug metabolism: have we overlooked their importance?Genetic and Nongenetic Factors Affecting Clopidogrel Response in the Egyptian Population.Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor.Quantitative proteomic analysis of hepatocyte-secreted extracellular vesicles reveals candidate markers for liver toxicityIdentification of carboxylesterase-dependent dabigatran etexilate hydrolysis.Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans.Nuclear receptor-mediated regulation of carboxylesterase expression and activity.Pharmacokinetic and Pharmacodynamic Responses to Clopidogrel: Evidences and Perspectives.Beyond efficacy: pharmacokinetic differences between clopidogrel, prasugrel and ticagrelor.Pharmacokinetic basis of the antiplatelet action of prasugrel.Comparative pharmacokinetics and pharmacodynamics of platelet adenosine diphosphate receptor antagonists and their clinical implications.Importance of potent P2Y(12) receptor blockade in acute myocardial infarction: focus on prasugrel.Advances in monitoring of aspirin therapy.Platelet function monitoring and clopidogrel.Metabolic differences of current thienopyridine antiplatelet agents.Identifying determinants of variability to tailor aspirin therapy.Front-loading with clopidogrel plus aspirin followed by dual antiplatelet therapy in the prevention of early stroke recurrence.Review of pharmacokinetic and pharmacodynamic modeling and safety of proton pump inhibitors and aspirin.Role of Genetic Testing in Patients undergoing Percutaneous Coronary Intervention.Drug delivery and therapeutic impact of extended-release acetylsalicylic acid.Regulations of Xenobiotics and Endobiotics on Carboxylesterases: A Comprehensive Review.The genetic basis of antiplatelet and anticoagulant therapy: A pharmacogenetic review of newer antiplatelets (clopidogrel, prasugrel and ticagrelor) and anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban).Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).Efficient in vitro refolding and functional characterization of recombinant human liver carboxylesterase (CES1) expressed in E. coli.A highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications.Efficacy of aspirin (325 mg) + omeprazole (40 mg) in treating coronary artery disease.Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants.Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug.
P2860
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P2860
Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@ast
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@en
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@nl
type
label
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@ast
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@en
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@nl
prefLabel
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@ast
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@en
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@nl
P2093
P3181
P356
P1476
Antiplatelet agents aspirin an ...... the presence of ethyl alcohol
@en
P2093
Bingfang Yan
Chris Black
Dongfang Yang
Madhu Mukundan
Nathan Charpentier
P304
P3181
P356
10.1124/JPET.106.110577
P407
P577
2006-08-30T00:00:00Z