Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival
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Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosomeTwo interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug designDissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methodsThe Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification PathwayInhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallographyTrypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity to oxidative stressDual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovaniGenetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress ManagementKinetics and redox-sensitive oligomerisation reveal negative subunit cooperativity in tryparedoxin peroxidase of Trypanosoma brucei brucei.Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.Genetically modified organisms and visceral leishmaniasisThe parasite-specific trypanothione metabolism of trypanosoma and leishmania.Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus.A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.Trypanothione synthesis in crithidia revisited.Deception and manipulation: the arms of leishmania, a successful parasiteLeishmania major methionine sulfoxide reductase A is required for resistance to oxidative stress and efficient replication in macrophages.Target validation: linking target and chemical properties to desired product profileRole of cAMP Signaling in the Survival and Infectivity of the Protozoan Parasite, Leishmania donovani.Thioredoxin reductase and glutathione synthesis in Plasmodium falciparum.Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.Molecular mechanisms of in vitro betulin-induced apoptosis of Leishmania donovani.Polyamine metabolism in Leishmania: from arginine to trypanothione.Polyamine-trypanothione pathway: an update.Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the mitochondrial tryparedoxin peroxidase from Leishmania braziliensisDepletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes.Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.Trypanothione reductase activity is prominent in metacyclic promastigotes and axenic amastigotes of Leishmania amazonesis. Evaluation of its potential as a therapeutic target.Ellman's-reagent-mediated regeneration of trypanothione in situ: substrate-economical microplate and time-dependent inhibition assays for trypanothione reductase.Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculataThe metabolism of S-nitrosothiols in the trypanosomatids: the role of ovothiol A and trypanothione.ATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.Cloning, expression and dynamic simulation of TRYP6 from Leishmania major (MRHO/IR/75/ER).Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.Use of clomipramine as chemotherapy of the chronic phase of Chagas disease.Screening natural products database for identification of potential antileishmanial chemotherapeutic agents.A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation.
P2860
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P2860
Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Down-regulation of Leishmania ...... arasite intracellular survival
@ast
Down-regulation of Leishmania ...... arasite intracellular survival
@en
type
label
Down-regulation of Leishmania ...... arasite intracellular survival
@ast
Down-regulation of Leishmania ...... arasite intracellular survival
@en
prefLabel
Down-regulation of Leishmania ...... arasite intracellular survival
@ast
Down-regulation of Leishmania ...... arasite intracellular survival
@en
P2093
P2860
P356
P1476
Down-regulation of Leishmania ...... arasite intracellular survival
@en
P2093
A H Fairlamb
M L Cunningham
P2860
P304
P356
10.1073/PNAS.95.9.5311
P407
P577
1998-04-01T00:00:00Z