Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.
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Role of Leishmania (Leishmania) chagasi amastigote cysteine protease in intracellular parasite survival: studies by gene disruption and antisense mRNA inhibitionThe squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1In vitro and in vivo activity of a palladacycle complex on Leishmania (Leishmania) amazonensisIdentification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPBThe calpain inhibitor MDL28170 induces the expression of apoptotic markers in Leishmania amazonensis promastigotesS1 subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids.Approaches for the identification of potential excreted/secreted proteins of Leishmania major parasites.Studies on the CPA cysteine peptidase in the Leishmania infantum genome strain JPCM5.Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxificationIn situ immunolocalization and stage-dependent expression of a secretory serine protease in Leishmania donovani and its role as a vaccine candidate.Evidence that free GPI glycolipids are essential for growth of Leishmania mexicana.Overexpression of a single Leishmania major gene enhances parasite infectivity in vivo and in vitroBiochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.Subunit vaccination of mice against new world cutaneous leishmaniasis: comparison of three proteins expressed in amastigotes and six adjuvants.Heterogeneity of wild Leishmania major isolates in experimental murine pathogenicity and specific immune responseATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania majorHeme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1.CPDB: cysteine protease annotation database in Leishmania species.Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphataseLeishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.Promising therapeutic targets for antileishmanial drugs.Genetic characterization of glucose transporter function in Leishmania mexicanaHeparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8.Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survivalThe gp63 Gene Cluster Is Highly Polymorphic in Natural Leishmania (Viannia) braziliensis Populations, but Functional Sites Are Conserved.Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes.A potential role for ICP, a Leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite.Molecular and biochemical characterization of a cathepsin B-like protease family unique to Trypanosoma congolenseLoss of virulence in Leishmania donovani deficient in an amastigote-specific protein, A2.Cysteine Peptidase B Regulates Leishmania mexicana Virulence through the Modulation of GP63 Expression.Transgenic Leishmania and the immune response to infectionCharacterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania majorOverexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 responseDevelopment of protease inhibitors for protozoan infections.A novel organotellurium compound (RT-01) as a new antileishmanial agent.Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death.The genetics of Leishmania virulence.A zymographic study of metalloprotease activities in extracts and extracellular secretions of Leishmania (Viannia) braziliensis strains.
P2860
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P2860
Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Evidence from disruption of th ...... einases are virulence factors.
@en
Evidence from disruption of th ...... einases are virulence factors.
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type
label
Evidence from disruption of th ...... einases are virulence factors.
@en
Evidence from disruption of th ...... einases are virulence factors.
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prefLabel
Evidence from disruption of th ...... einases are virulence factors.
@en
Evidence from disruption of th ...... einases are virulence factors.
@nl
P2093
P2860
P356
P1476
Evidence from disruption of th ...... teinases are virulence factors
@en
P2093
G H Coombs
J E Hutchison
P2860
P304
P356
10.1073/PNAS.93.12.6008
P407
P577
1996-06-01T00:00:00Z