Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival. - Wikidata - awgldk - TriplyDB

Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival.

Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival.

http://www.wikidata.org/entity/Q36070080

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Comprehensive molecular portraits of human breast tumours The quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stability Differential pathogenesis of lung adenocarcinoma subtypes involving sequence mutations, copy number, chromosomal instability, and methylation Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data Genome instability in blood cells of a BRCA1+ breast cancer family.Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts.Remodeling of the methylation landscape in breast cancer metastasis.Using Drosophila melanogaster to identify chemotherapy toxicity genes.Micro-scale genomic DNA copy number aberrations as another means of mutagenesis in breast cancer.PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.Triple negative breast cancers have a reduced expression of DNA repair genes An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer.Gene aberrations of RRM1 and RRM2B and outcome of advanced breast cancer after treatment with docetaxel with or without gemcitabine.Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity.Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN Enriched transcription factor signatures in triple negative breast cancer indicates possible targeted therapies with existing drugs.Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.Personalized medicine for patients with advanced cancer in the phase I program at MD Anderson: validation and landmark analyses.Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study.Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases Basal-like breast cancer: molecular profiles, clinical features and survival outcomes Breast cancer regulated by Fringe.miR-548d-3p/TP53BP2 axis regulates the proliferation and apoptosis of breast cancer cells.Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer.Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers.Somatic copy number changes in DPYD are associated with lower risk of recurrence in triple-negative breast cancers.Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest.CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations.Plk2 regulates mitotic spindle orientation and mammary gland development EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor.Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.Metformin attenuates transforming growth factor beta (TGF-β) mediated oncogenesis in mesenchymal stem-like/claudin-low triple negative breast cancer.Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer.TP53 Mutations in Breast and Ovarian Cancer.Biological Subtypes of Triple-Negative Breast Cancer.Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling.Gene expression-based classifications of fibroadenomas and phyllodes tumours of the breast.

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P2860

Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival.

http://www.wikidata.org/entity/Q36070080

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Andrew Nobel

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Andrey A Shabalin

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Chika Nwachukwu

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Dezheng Huo

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Hann-Hsiang Chao

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Joel S Parker

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Tatyana Grushko

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Victor J Weigman

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Xiaping He

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P2860

Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

A gene-expression signature as a predictor of survival in breast cancer

The consensus coding sequences of human breast and colorectal cancers

The genomic landscapes of human breast and colorectal cancers

Molecular portraits of human breast tumours

Repeated observation of breast tumor subtypes in independent gene expression data sets

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Anne-Lise Børresen-Dale

Charles M. Perou

Vessela Kristensen

Silje H. Nordgard

Olufunmilayo Olopade

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