Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP. - Wikidata - awgldk - TriplyDB

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.

http://www.wikidata.org/entity/Q36072002

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Impact of Pancreatic Rat Islet Density on Cell Survival during Hypoxia.Intermittent hypoxia-induced rat pancreatic β-cell apoptosis and protective effects of antioxidant intervention.Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes.Bone Marrow Mesenchymal Stem Cells Attenuate Mitochondria Damage Induced by Hypoxia in Mouse Trophoblasts.Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells Interactions between oxygen homeostasis, food availability, and hydrogen sulfide signaling.Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction.Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis.The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.Polyelectrolyte multilayered assemblies in biomedical technologies.Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia.Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.Ribosome profiling reveals translational regulation of mammalian cells in response to hypoxic stress The Influence of Stabilized Deconjugated Ursodeoxycholic Acid on Polymer-Hydrogel System of Transplantable NIT-1 Cells.Cell-Permeable Peptide Blocks TLR4 Signaling and Improves Islet Allograft Survival.β-cell differentiation status in type 2 diabetes.β-Cell dysfunction in diabetes: a crisis of identity?Shielding Engineered Islets With Mesenchymal Stem Cells Enhance Survival Under Hypoxia.Apoptosis and reduced microvascular density of the lamina propria during tooth eruption in rats.Culturing with modified EGM2 medium enhances porcine neonatal islet-like cell clusters resistance to apoptosis in islet xenotransplantation.Carbon Monoxide Inhibits Islet Apoptosis via Induction of Autophagy.Neurodegeneration: Keeping ATF4 on a Tight Leash.Overexpression of appoptosin promotes mitochondrial damage in MIN6 cells.Oxygen-permeable microwell device maintains islet mass and integrity during shipping.Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death.Identification of ASB7 as ER stress responsive gene through a genome wide in silico screening for genes with ERSE.Low Oxygen Levels Induce Early Luteinization Associated Changes in Bovine Granulosa Cells

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P2860

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.

http://www.wikidata.org/entity/Q36072002

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2012年の論文

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Acute hypoxia induces apoptosi ...... onse and upregulation of CHOP.

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Acute hypoxia induces apoptosi ...... onse and upregulation of CHOP.

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Acute hypoxia induces apoptosi ...... onse and upregulation of CHOP.

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Acute hypoxia induces apoptosi ...... onse and upregulation of CHOP.

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Acute hypoxia induces apoptosi ...... ponse and upregulation of CHOP

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A Björklund

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I Botusan

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L Poellinger

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P2860

Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Regulated translation initiation controls stress-induced gene expression in mammalian cells

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

ER stress triggers apoptosis by activating BH3-only protein Bim

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.

The human PDI family: versatility packed into a single fold.

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10.1038/CDDIS.2012.66

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Kerstin Brismar

Sergiu Bogdan Catrina

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