Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. - Wikidata - awgldk - TriplyDB

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

http://www.wikidata.org/entity/Q36080392

about

Wnt/beta-catenin signaling and small molecule inhibitors Development of anticancer agents targeting the Wnt/β-catenin signaling Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine Identification of key residues and regions important for porcupine-mediated Wnt acylation The development of highly potent inhibitors for porcupine.The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.Triple-negative breast cancer: new perspectives for targeted therapies.Fatty acyl donor selectivity in membrane bound O-acyltransferases and communal cell fate decision-making.Wnt acylation and its functional implication in Wnt signalling regulation Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Generation and application of signaling pathway reporter lines in zebrafish Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer.WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins.Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.Biochemical Analysis of Tankyrase Activity in Zebrafish In Vitro and In Vivo.Palmitoylation of proteins in cancer.Revisiting the role of Wnt/β-catenin signaling in prostate cancer.Delivery of the Porcupine Inhibitor WNT974 in Mice.Monitoring Wnt Protein Acylation Using an In Vitro Cyclo-Addition Reaction Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling.Identification of the WNT1 residues required for palmitoylation by Porcupine.Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors.Development of a triazole class of highly potent Porcn inhibitors.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.Bidirectional reporter assay using HAL promoter and TOPFLASH improves specificity in high-throughput screening of Wnt inhibitors.Monitoring Wnt Signaling in Zebrafish Using Fluorescent Biosensors.Wnt signaling in cancer.Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression.

P2860

Q24597197-32E1C0D9-712F-4F7A-A021-734D5E18B860 Q26781898-F53A5C45-A517-4226-A637-86CB58F877B4 Q26796673-BA459221-076D-46B3-8E07-583D1E68F3C1 Q28584812-198E139F-C0BA-40E0-9803-7D2ECAF7817C Q34616057-6576210B-049F-4BFB-B462-EC1395D3039B Q34880355-9C6047AF-F706-4A82-81FC-795477324509 Q35001758-53D9022A-3C47-4AF6-BDCF-EB17EE5F6698 Q35500434-8C64D1D4-CF0F-4626-AF45-29BE478A7FE3 Q35652444-B94B74E6-BC29-486E-BDA5-2824BAD24125 Q35869295-70118B83-A192-4FAF-8093-9296C01FCF07 Q36878238-A20E7D01-3211-46AF-A57B-F5E3058A76B6 Q36919396-3E412A29-42AA-4097-A695-24EB10317429 Q37279028-E34520BE-371F-46B3-962D-F01EE3B61935 Q37305230-263B52DD-FCB6-41D3-B31F-5B6A709ED2A1 Q37353317-DF43936B-2C9B-4D07-A6A7-714E0D77B2A2 Q37395251-F5C69E57-EDE5-4017-AE78-604123CB45E8 Q38410995-81B5E3A1-D520-49A5-8DE9-9EC8C9D54947 Q38837607-25A8369C-3AAE-4999-B9F0-1D5C2C468A2C Q39131794-B54C4C0F-2DA8-45D8-93F7-D81AE033A124 Q39427225-DBB646BF-6202-442A-B6B3-D9D846ADDBAC Q41093500-4592AF54-D600-4110-B161-7DF2E4FE4C80 Q41153574-0110511E-75AE-4F48-9AB1-0E1C33F66AA0 Q41753868-9E127E7D-3D11-4806-8B0D-F32EA8B73FB9 Q42281552-6646E3E2-3871-4656-84E0-3658AE477AF9 Q47139083-3A3CCF09-CBAD-4D25-9E66-05160FD25263 Q47239374-98F6F445-0982-4B13-946E-CF9EFBAC10ED Q48013783-F737800F-A746-4475-8030-CFBBACC2EB01 Q50220575-8F2402F4-B38B-47A9-8961-863253CAC78D Q51518956-546B0FB3-AEAB-4604-B89E-1CFAE5A4D12F Q52658725-8EA72B6E-31A1-4C6F-9474-87FE65E5C795 Q55145186-6FB97683-6B2D-48DF-8CDA-6D5B86F28EFE

P2860

Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine.

http://www.wikidata.org/entity/Q36080392

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Diverse chemical scaffolds sup ...... d O-acyltransferase porcupine.

@ast

Diverse chemical scaffolds sup ...... d O-acyltransferase porcupine.

@en

type

label

Diverse chemical scaffolds sup ...... d O-acyltransferase porcupine.

@ast

Diverse chemical scaffolds sup ...... d O-acyltransferase porcupine.

@en

prefLabel

Diverse chemical scaffolds sup ...... d O-acyltransferase porcupine.

@ast

Diverse chemical scaffolds sup ...... d O-acyltransferase porcupine.

@en

P1433

Q36080392-1FEBD6C3-DFB3-48E4-B70A-38D333705FCD

P1476

Q36080392-C2A584FA-5855-460B-82EE-BA79FE0C41B3

P2093

Q36080392-45FAFE3C-CD1D-469B-B353-59F2B7070D90

Q36080392-60497714-8372-408A-B69C-E5C37EEEE904

Q36080392-66F1E30A-0E84-4F3C-9F10-F867FDD6471D

Q36080392-8F460301-6161-44C4-A311-295F90948096

Q36080392-93DFA8EF-5944-44B0-A023-B06D14569413

Q36080392-972894D6-FBC2-4502-B557-99CB073B84C2

Q36080392-A0A8B71D-DB2D-4127-BA10-C4A017AD0FF1

Q36080392-A5E17FB4-2675-484D-BEF4-58008AF87B2B

Q36080392-A86F18BD-8E5B-468C-AB07-893F974E69AE

Q36080392-BD9A1C92-E0A4-487E-ADE6-537ED3A2C3DD

P2860

Q36080392-1FAD2F38-72FE-4ED8-BBE9-9766A966B827

Q36080392-1FBEE237-8BAC-43B5-B8B2-32F79FA65153

Q36080392-1FFE5474-0F5A-4FAA-9441-786C3885EBC5

Q36080392-338183FD-5631-4195-88B8-F2C4ED937F1C

Q36080392-41A52DD4-4CF5-4DAE-B04D-EBF4A0A14384

Q36080392-42D4F8ED-90E2-4ECA-8255-83BA26EB68D1

Q36080392-46B814B9-3A4D-4802-B8DF-B639FFE7F507

Q36080392-5ADAEC27-9AD8-41A4-A6D3-DEE591D38A8E

Q36080392-6478277D-B316-44C8-9F75-AC05CE931EB9

Q36080392-6C476263-91A5-43BA-81B0-3CD5B6683D1A

P304

Q36080392-F355AA81-2030-4310-8F14-9183E0D0F009

P31

Q36080392-C0D30CC4-DAB0-42E6-9855-9DCAB8CEB5DF

P356

Q36080392-A23E6836-F2C1-42A0-977C-CDDF5B4F61E6

P407

Q36080392-C70AC8BF-C34A-412D-932B-E5F8396A3405

P433

Q36080392-67188DB7-5C84-4206-87AB-59E041FC55FA

P478

Q36080392-D756D193-627D-45E7-A477-3EC7DF6A24AC

P50

Q36080392-36C6694C-6BEF-4BCF-AC20-2188977D580E

Q36080392-AA08B718-7F28-4CDD-9641-A126794CFAA8

Q36080392-F32A358B-9DEA-4AE8-B356-391E01D23EA0

P577

Q36080392-55BA4EAA-2E94-478F-8199-F3C24068BAE3

P5875

Q36080392-BF5B775E-D0B5-42B9-B9A1-61B84963C84B

P698

Q36080392-4C25DC6F-1932-46D7-8F09-0C88DA1009DA

P932

Q36080392-9198F046-1324-44AE-ACA5-A89290F62694

P356

JBC.M112.372029

P1433

Journal of Biological Chemistry

P1476

Diverse chemical scaffolds sup ...... d O-acyltransferase porcupine.

@en

P2093

Courtney M Karner

http://www.w3.org/2001/XMLSchema#string

Francesco Argenton

http://www.w3.org/2001/XMLSchema#string

Heping Shi

http://www.w3.org/2001/XMLSchema#string

James F Amatruda

http://www.w3.org/2001/XMLSchema#string

Jesung Moon

http://www.w3.org/2001/XMLSchema#string

Jianming Lu

http://www.w3.org/2001/XMLSchema#string

Lawrence Lum

http://www.w3.org/2001/XMLSchema#string

Leni S Jacob

http://www.w3.org/2001/XMLSchema#string

Li-shu Zhang

http://www.w3.org/2001/XMLSchema#string

Michael E Dodge

http://www.w3.org/2001/XMLSchema#string

P2860

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone

Towards an integrated view of Wnt signaling in development

Proximal events in Wnt signal transduction

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway.

RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer.

P304

23246-23254

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M112.372029

http://www.w3.org/2001/XMLSchema#string

P407

P433

27

http://www.w3.org/2001/XMLSchema#string

P478

287

http://www.w3.org/2001/XMLSchema#string

P50

Alessandro Mongera

P577

2012-05-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

224972603

http://www.w3.org/2001/XMLSchema#string

P698

22593577

http://www.w3.org/2001/XMLSchema#string

P932

3391103

http://www.w3.org/2001/XMLSchema#string