A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
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DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKRThe B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKRToll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signalingViral apoptosis is induced by IRF-3-mediated activation of BaxPACT, a protein activator of the interferon-induced protein kinase, PKR.Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR)Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPKTRAF family proteins link PKR with NF-kappa B activationThe molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirusThe C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinaseAntiviral actions of interferonsModular structure of PACT: distinct domains for binding and activating PKRRAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infectionImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionDoes protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a vaccinia virus recombinantPro-Apoptotic Kinase Levels in Cerebrospinal Fluid as Potential Future Biomarkers in Alzheimer's DiseaseCoronavirus gene 7 counteracts host defenses and modulates virus virulenceControl of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.Stable high-level expression of heterologous genes in vitro and in vivo by noncytopathic DNA-based Kunjin virus replicon vectorsAntiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinaseRegulation of PKR and IRF-1 during hepatitis C virus RNA replication.Cancer therapy using a self-replicating RNA vaccineThe response of mammalian cells to double-stranded RNAThe double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitroA novel role for RAX, the cellular activator of PKR, in synergistically stimulating SV40 large T antigen-dependent gene expressionCharacterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKRThe anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCCTranslation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylationEnhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinaseMechanisms of beta-cell death in response to double-stranded (ds) RNA and interferon-gamma: dsRNA-dependent protein kinase apoptosis and nitric oxide-dependent necrosisThe protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxinSatratoxin G-induced apoptosis in PC-12 neuronal cells is mediated by PKR and caspase independentExogenous gamma and alpha/beta interferon rescues human macrophages from cell death induced by Bacillus anthracisThe chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cellsProapoptotic protein PACT is expressed at high levels in colonic epithelial cells in miceInhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cellsEffect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alphaToll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells
P2860
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P2860
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A double-stranded RNA-activate ...... ating stress-induced apoptosis
@ast
A double-stranded RNA-activate ...... ating stress-induced apoptosis
@en
type
label
A double-stranded RNA-activate ...... ating stress-induced apoptosis
@ast
A double-stranded RNA-activate ...... ating stress-induced apoptosis
@en
prefLabel
A double-stranded RNA-activate ...... ating stress-induced apoptosis
@ast
A double-stranded RNA-activate ...... ating stress-induced apoptosis
@en
P2093
P2860
P356
P1476
A double-stranded RNA-activate ...... ating stress-induced apoptosis
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.7.3279
P407
P577
1997-04-01T00:00:00Z