Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
about
Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2Crystal structure of human cytochrome P450 2D6Crystal structure of the human prostacyclin synthaseCYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligasesStructural basis for androgen specificity and oestrogen synthesis in human aromataseStructures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substratesStructural and mechanistic insights into the interaction of cytochrome P4503A4 with bromoergocryptine, a type I ligandCYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffoldsSubstrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductaseKinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenesInteractions between CYP3A4 and Dietary PolyphenolsUnderstanding the mechanism of cytochrome P450 3A4: recent advances and remaining problemsThe structural biology of oestrogen metabolismA novel type of allosteric regulation: functional cooperativity in monomeric proteinsStructural diversity of eukaryotic membrane cytochrome p450sStructural insight into the altered substrate specificity of human cytochrome P450 2A6 mutantsModes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthaseCrystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1 H -imidazole: Ligand-Induced Structural Response through α-Helical Repositioning ,Crystal Structure of CYP24A1, a Mitochondrial Cytochrome P450 Involved in Vitamin D MetabolismStructural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruziPlasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray CrystallographyStructure and mechanism of the complex between cytochrome P4503A4 and ritonavirStructural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantumCrystal Structure of H2O2-dependent Cytochrome P450SP with Its Bound Fatty Acid Substrate: INSIGHT INTO THE REGIOSELECTIVE HYDROXYLATION OF FATTY ACIDS AT THE POSITIONPyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than RitonavirInteraction of human cytochrome P4503A4 with ritonavir analogsStructural Basis for the Functional Roles of Critical Residues in Human Cytochrome P450 AromataseArchitecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayerDiscovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical UtilityRecent progress in robot-based systems for crystallography and their contribution to drug discoveryStructural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyIdentifying cytochrome p450 functional networks and their allosteric regulatory elementsUnderstanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450sA multiscale approach to modelling drug metabolism by membrane-bound cytochrome P450 enzymesComparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variantsMolecular evolution and functional divergence of the cytochrome P450 3 (CYP3) Family in Actinopterygii (ray-finned fish)Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics.Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.
P2860
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P2860
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@ast
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@en
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@en-gb
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@nl
type
label
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@ast
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@en
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@en-gb
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@nl
prefLabel
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@ast
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@en
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@en-gb
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@nl
P2093
P921
P3181
P356
P1433
P1476
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
@en
P2093
Alison Ward
Harren Jhoti
Hayley C Angove
Ian J Tickle
Jose Cosme
Pamela A Williams
Philip J Day
P3181
P356
10.1126/SCIENCE.1099736
P407
P577
2004-07-30T00:00:00Z