The efficiency of multi-target drugs: the network approach might help drug design.
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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesParallel visualization of multiple protein complexes in individual cells in tumor tissueGenome-environment interactions that modulate aging: powerful targets for drug discoveryNavigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's DiseaseHuman Prostate Cancer Hallmarks MapStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewAttenuation of renovascular damage in Zucker diabetic fatty rat by NWT-03, an egg protein hydrolysate with ACE- and DPP4-inhibitory ActivityFunctional connectivity in islets of Langerhans from mouse pancreas tissue slicesA ranking method for the concurrent learning of compounds with various activity profiles.Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain ManagementMonoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target DrugsKey Targets for Multi-Target Ligands Designed to Combat NeurodegenerationDual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugsAdvances in Integrative Nanomedicine for Improving Infectious Disease Treatment in Public HealthIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesA novel network model identified a 13-gene lung cancer prognostic signatureIntegrated DNA Copy Number and Gene Expression Regulatory Network Analysis of Non-small Cell Lung Cancer MetastasisOptimized hydrophobic interactions and hydrogen bonding at the target-ligand interface leads the pathways of drug-designingPre-clinical drug prioritization via prognosis-guided genetic interaction networksA network-based multi-target computational estimation scheme for anticoagulant activities of compoundsDrug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavirModularity in protein complex and drug interactions reveals new polypharmacological propertiesProteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosisMulti-target drugs: the trend of drug research and developmentWithaferin-A reduces type I collagen expression in vitro and inhibits development of myocardial fibrosis in vivoWhat does it take to synergistically combine sub-potent natural products into drug-level potent combinations?An innovative strategy for dual inhibitor design and its application in dual inhibition of human thymidylate synthase and dihydrofolate reductase enzymesPerturbation centrality and turbine: a novel centrality measure obtained using a versatile network dynamics toolCombining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacologyThe use of functional chemical-protein associations to identify multi-pathway renoprotectantsDesired alteration of protein affinities: competitive selection of protein variants using yeast signal transduction machineryA Network-Based Target Overlap Score for Characterizing Drug Combinations: High Correlation with Cancer Clinical Trial ResultsA Multilayer Network Approach for Guiding Drug Repositioning in Neglected DiseasesInference of Gene Regulatory Network Based on Local Bayesian NetworksPhIN: A Protein Pharmacology Interaction Network DatabaseSystems Medicine 2.0: potential benefits of combining electronic health care records with systems science modelsExploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computingMembrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane raftsNetwork medicine: a network-based approach to human diseaseDual function of TGFβ in lens epithelial cell fate: implications for secondary cataract.
P2860
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P2860
The efficiency of multi-target drugs: the network approach might help drug design.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The efficiency of multi-target drugs: the network approach might help drug design.
@ast
The efficiency of multi-target drugs: the network approach might help drug design.
@en
type
label
The efficiency of multi-target drugs: the network approach might help drug design.
@ast
The efficiency of multi-target drugs: the network approach might help drug design.
@en
prefLabel
The efficiency of multi-target drugs: the network approach might help drug design.
@ast
The efficiency of multi-target drugs: the network approach might help drug design.
@en
P2093
P1476
The efficiency of multi-target drugs: the network approach might help drug design.
@en
P2093
Péter Csermely
Sándor Pongor
Vilmos Agoston
P304
P356
10.1016/J.TIPS.2005.02.007
P577
2005-04-01T00:00:00Z
P5875
P698
P818
q-bio/0412045