Protein stability imposes limits on organism complexity and speed of molecular evolution.
about
Predictability of evolutionary trajectories in fitness landscapesIn the light of directed evolution: pathways of adaptive protein evolutionMerging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population geneticsThe interface of protein structure, protein biophysics, and molecular evolutionAdaptive protein evolution grants organismal fitness by improving catalysis and flexibilityAn evolutionary model-based algorithm for accurate phylogenetic breakpoint mapping and subtype prediction in HIV-1Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations?Correlated electrostatic mutations provide a reservoir of stability in HIV proteaseStochastic simulations suggest that HIV-1 survives close to its error thresholdA model of proteostatic energy cost and its use in analysis of proteome trends and sequence evolutionProtein Thermostability Is Owing to Their Preferences to Non-Polar Smaller Volume Amino Acids, Variations in Residual Physico-Chemical Properties and More Salt-BridgesSelection for Protein Kinetic Stability Connects Denaturation Temperatures to Organismal Temperatures and Provides Clues to Archaean LifeContingency and entrenchment in protein evolution under purifying selectionLethal mutagenesis of bacteriaAmino acid composition of proteins reduces deleterious impact of mutations.Improvisation in evolution of genes and genomes: whose structure is it anyway?Protein Destabilization as a Common Factor in Diverse Inherited Disorders.Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection.The Role of Evolutionary Selection in the Dynamics of Protein Structure Evolution.A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase.Protein biophysics explains why highly abundant proteins evolve slowlyFisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype spaceInferring stabilizing mutations from protein phylogenies: application to influenza hemagglutinin.Universal distribution of protein evolution rates as a consequence of protein folding physicsInterplay between pleiotropy and secondary selection determines rise and fall of mutators in stress response.Mutation bias favors protein folding stability in the evolution of small populationsEnzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease.A zinc-binding site by negative selection induces metallodrug susceptibility in an essential chaperonin.Cellular proteomes have broad distributions of protein stabilityInterplay between chaperones and protein disorder promotes the evolution of protein networks.Role of conservative mutations in protein multi-property adaptationBiophysical and structural considerations for protein sequence evolutionPolyglutamine shows a urea-like affinity for unfolded cytosolic protein.Engineering a large protein by combined rational and random approaches: stabilizing the Clostridium thermocellum cellobiose phosphorylase.Bringing molecules back into molecular evolution.Evolutionary biochemistry: revealing the historical and physical causes of protein properties.Mutation induced extinction in finite populations: lethal mutagenesis and lethal isolation.Opposing effects of folding and assembly chaperones on evolvability of Rubisco.The influence of selection for protein stability on dN/dS estimations
P2860
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P2860
Protein stability imposes limits on organism complexity and speed of molecular evolution.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Protein stability imposes limits on organism complexity and speed of molecular evolution.
@ast
Protein stability imposes limits on organism complexity and speed of molecular evolution.
@en
type
label
Protein stability imposes limits on organism complexity and speed of molecular evolution.
@ast
Protein stability imposes limits on organism complexity and speed of molecular evolution.
@en
prefLabel
Protein stability imposes limits on organism complexity and speed of molecular evolution.
@ast
Protein stability imposes limits on organism complexity and speed of molecular evolution.
@en
P2860
P356
P1476
Protein stability imposes limits on organism complexity and speed of molecular evolution.
@en
P2093
Konstantin B Zeldovich
Peiqiu Chen
P2860
P304
16152-16157
P356
10.1073/PNAS.0705366104
P407
P577
2007-10-03T00:00:00Z