Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms.
about
Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamerCardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium ChannelsMechanism of the modulation of Kv4:KChIP-1 channels by external K+Insight into specific pro-arrhythmic triggers in Brugada and early repolarization syndromes: results of long-term follow-up.Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection.Functional and pharmacological characterization of a Shal-related K+ channel subunit in ZebrafishNon-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating.The cellular force-frequency response in ventricular myocytes from the varanid lizard, Varanus exanthematicus.Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulationKCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders.Cardiac Ion Channel Regulation in Obesity and the Metabolic Syndrome: Relevance to Long QT Syndrome and Atrial FibrillationMulti-walled carbon nanotubes impair Kv4.2/4.3 channel activities, delay membrane repolarization and induce bradyarrhythmias in the rat.Electrophysiological remodeling in heart failureThe membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner.High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the accessory protein KChIP2.Time- and voltage-dependent components of Kv4.3 inactivation.K(V)4.3 N-terminal deletion mutant Δ2-39: effects on inactivation and recovery characteristics in both the absence and presence of KChIP2b.Effects of boundaries and geometry on the spatial distribution of action potential duration in cardiac tissue.Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk.Analysis of the contribution of I(to) to repolarization in canine ventricular myocardium.The "structurally minimal" isoform KChIP2d modulates recovery of K(v)4.3 N-terminal deletion mutant Δ2-39Free Fatty Acid Effects on the Atrial Myocardium: Membrane Ionic Currents Are Remodeled by the Disruption of T-Tubular ArchitectureEvolution of CpG island promoter function underlies changes in KChIP2 potassium channel subunit gene expression in mammalian heart.Alk7 Depleted Mice Exhibit Prolonged Cardiac Repolarization and Are Predisposed to Ventricular Arrhythmia.Impact of KChIP2 on Cardiac Electrophysiology and the Progression of Heart Failure.Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells.Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.The plateau outward current in canine ventricle, sensitive to 4-aminopyridine, is a constitutive contributor to ventricular repolarizationKChIP2 genotype dependence of transient outward current (Ito) properties in cardiomyocytes isolated from male and female mice.Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles.A role for DPPX modulating external TEA sensitivity of Kv4 channels.Principles of safety pharmacology.Modulation of ventricular transient outward K⁺ current by acidosis and its effects on excitation-contraction coupling.Molecular Basis of Functional Myocardial Potassium Channel Diversity.Modification of K+ channel-drug interactions by ancillary subunits.The neuronal Kv4 channel complex.Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium.Association of the Kv1 family of K+ channels and their functional blueprint in the properties of auditory neurons as revealed by genetic and functional analyses.S3b amino acid substitutions and ancillary subunits alter the affinity of Heteropoda venatoria toxin 2 for Kv4.3.
P2860
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P2860
Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Transient outward potassium cu ...... ar and biophysical mechanisms.
@ast
Transient outward potassium cu ...... ar and biophysical mechanisms.
@en
type
label
Transient outward potassium cu ...... ar and biophysical mechanisms.
@ast
Transient outward potassium cu ...... ar and biophysical mechanisms.
@en
prefLabel
Transient outward potassium cu ...... ar and biophysical mechanisms.
@ast
Transient outward potassium cu ...... ar and biophysical mechanisms.
@en
P2860
P1476
Transient outward potassium cu ...... ar and biophysical mechanisms.
@en
P2093
Donald L Campbell
P2860
P356
10.1113/JPHYSIOL.2005.086223
P407
P577
2005-04-14T00:00:00Z