Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia
about
Form and function: how estrogen and progesterone regulate the mammary epithelial hierarchyLesion complexity drives age related cancer susceptibility in human mammary epithelial cells.Minireview: Progesterone Regulation of Proliferation in the Normal Human Breast and in Breast Cancer: A Tale of Two Scenarios?Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitorsAcquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease.Cell-type specific DNA methylation patterns define human breast cellular identity.Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells.Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobulesA strategy for tissue self-organization that is robust to cellular heterogeneity and plasticityAge and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cellsBreast primary epithelial cells that escape p16-dependent stasis enter a telomere-driven crisis state.Laser Capture Microdissection as a Tool to Study Tumor Stroma.Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations.Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potentialProcessing of human reduction mammoplasty and mastectomy tissues for cell cultureCell Fate Decisions During Breast Cancer Development.Breast Cancer beyond the Age of Mutation.Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length.Characterization of mammary epithelial stem/progenitor cells and their changes with aging in common marmosetsKeratins Are Altered in Intestinal Disease-Related Stress Responses.Cellular senescence mediated by p16INK4A-coupled miRNA pathways.Impact of progesterone on stem/progenitor cells in the human breast.Progesterone stimulates progenitor cells in normal human breast and breast cancer cells.Constitutive activation of RANK disrupts mammary cell fate leading to tumorigenesis.Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice.Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer.Proof of region-specific multipotent progenitors in human breast epithelia.Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells.Opportunities for organoids as new models of aging.Cell and Tissue Biology Paves a Path to Breast Cancer Prevention.CD49f+ mammary epithelial cells decrease in milk from dairy cows stressed by overstocking during the dry period.Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance.High-Dimensional Phenotyping Identifies Age-Emergent Cells in Human Mammary Epithelia.Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.Stem cells: Repeat to fade
P2860
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P2860
Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Accumulation of multipotent pr ...... ing of human mammary epithelia
@ast
Accumulation of multipotent pr ...... ing of human mammary epithelia
@en
type
label
Accumulation of multipotent pr ...... ing of human mammary epithelia
@ast
Accumulation of multipotent pr ...... ing of human mammary epithelia
@en
prefLabel
Accumulation of multipotent pr ...... ing of human mammary epithelia
@ast
Accumulation of multipotent pr ...... ing of human mammary epithelia
@en
P2093
P2860
P50
P1433
P1476
Accumulation of multipotent pr ...... ing of human mammary epithelia
@en
P2093
Alexander D Borowsky
Diana E Guo
Fanny A Pelissier
Francois Pepin
James C Garbe
Klara Sputova
Mark A Labarge
Martha R Stampfer
Morag Park
P2860
P304
P356
10.1158/0008-5472.CAN-12-0157
P407
P577
2012-05-02T00:00:00Z