The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.
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Illuminating Spatial and Temporal Organization of Protein Interaction Networks by Mass Spectrometry-Based ProteomicsMicro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient MiceMeet the neighbors: Mapping local protein interactomes by proximity-dependent labeling with BioIDCerebral Cavernous Malformations: Review of the Genetic and Protein-Protein Interactions Resulting in Disease PathogenesisStructural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interfaceKLF4 is a key determinant in the development and progression of cerebral cavernous malformations.Combined HMG-COA reductase and prenylation inhibition in treatment of CCM.Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential.The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3.An improved smaller biotin ligase for BioID proximity labeling.Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.Introduction to cerebral cavernous malformation: a brief review.Endothelial fluid shear stress sensing in vascular health and disease.Filling the Void: Proximity-Based Labeling of Proteins in Living Cells.The molecular basis of endothelial cell plasticity.Measuring Kinase Activity-A Global Challenge.Linking Brain Arteriovenous Malformations With Anorectal Hemorrhoids: A Clinical and Anatomical Review.Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis.Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis.Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformationsSystematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations
P2860
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P2860
The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The cerebral cavernous malform ...... signaling and KLF expression.
@ast
The cerebral cavernous malform ...... signaling and KLF expression.
@en
type
label
The cerebral cavernous malform ...... signaling and KLF expression.
@ast
The cerebral cavernous malform ...... signaling and KLF expression.
@en
prefLabel
The cerebral cavernous malform ...... signaling and KLF expression.
@ast
The cerebral cavernous malform ...... signaling and KLF expression.
@en
P2093
P2860
P1433
P1476
The cerebral cavernous malform ...... 3 signaling and KLF expression
@en
P2093
Benjamin A Garcia
David R Rawnsley
J Simon C Arthur
Jisheng Yang
Kevin J Whitehead
Lauren M Goddard
Mark L Kahn
P2860
P304
P356
10.1016/J.DEVCEL.2014.12.009
P407
P577
2015-01-01T00:00:00Z