Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
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Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationObesity and insulin resistanceRoles of renal proximal tubule transport in acid/base balance and blood pressure regulationExtracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistanceSelective modulation of the CAP/Cbl pathway in the adipose tissue of high fat diet treated ratsAdipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesityThe induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes.Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistanceDiabetes and the role of inositol-containing lipids in insulin signalingDegradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/JngInsulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis.Insulin signaling and action in fat cells: associations with insulin resistance and type 2 diabetes.Prostaglandylinositol cyclic phosphate (cPIP): a novel second messenger of insulin action. Comparative analysis of two kinds of "insulin mediators".Lasting effects on body weight and mammary gland gene expression in female mice upon early life exposure to n-3 but not n-6 high-fat diets.Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.Metabolic effects of obesity: A reviewInsulin resistance, obesity, hypertension, and renal sodium transport.Insulin resistant states and insulin signaling.The WNT inhibitor Dickkopf 1 and bone morphogenetic protein 4 rescue adipogenesis in hypertrophic obesity in humans.The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance.Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesitySpatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks.Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases.Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscleRole of renal proximal tubule transport in thiazolidinedione-induced volume expansion.Short-term overeating induces insulin resistance in fat cells in lean human subjects.High fat diet induced obesity alters ovarian phosphatidylinositol-3 kinase signaling gene expression.Separation of insulin signaling into distinct GLUT4 translocation and activation steps.PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization.IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms.A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue.Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells.Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes.The role of renal proximal tubule transport in the regulation of blood pressure.
P2860
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P2860
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Insulin receptor substrate (IR ...... n-dependent diabetes mellitus.
@ast
Insulin receptor substrate (IR ...... n-dependent diabetes mellitus.
@en
type
label
Insulin receptor substrate (IR ...... n-dependent diabetes mellitus.
@ast
Insulin receptor substrate (IR ...... n-dependent diabetes mellitus.
@en
prefLabel
Insulin receptor substrate (IR ...... n-dependent diabetes mellitus.
@ast
Insulin receptor substrate (IR ...... n-dependent diabetes mellitus.
@en
P2093
P2860
P356
P1476
Insulin receptor substrate (IR ...... n-dependent diabetes mellitus.
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.8.4171
P407
P577
1997-04-01T00:00:00Z