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Targeting DNA Replication Stress for Cancer TherapyA Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in CardiomyocytesThe p53 pathway as a target in cancer therapeutics: obstacles and promiseDiscovery and optimization of small-molecule ligands for the CBP/p300 bromodomainsTwo strategies for the development of mitochondrion-targeted small molecule radiation damage mitigatorsA mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced deathMolecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cellsMultiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cellsDynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention.Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancerInhibition of human parainfluenza virus type 3 infection by novel small moleculesShort-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantationPathologies associated with the p53 response.Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models.Inflammation and p53: A Tale of Two StressesInactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-moleculeA small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer.p53-based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study.Synergistic cytotoxic effects of recombinant human adenovirus p53 and radiation at various time points in A549 lung adenocarcinoma cells.p53 functions in endothelial cells to prevent radiation-induced myocardial injury in miceCyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.Dangerous habits of a security guard: the two faces of p53 as a drug target.Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model.Functional TauT protects against acute kidney injury.siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injuryHuman papillomavirus oncogenic E6 protein regulates human β-defensin 3 (hBD3) expression via the tumor suppressor protein p53.Activation and involvement of p53 in cisplatin-induced nephrotoxicity.A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.Radioprotection: smart games with death.Transcriptional modulation induced by ionizing radiation: p53 remains a central player.p53 and the Carcinogenicity of Chronic Inflammation.Activation of p53-dependent/-independent pathways of apoptotic cell death by chelerythrine in a murine T cell lymphoma.Sequential transcription factor targeting for diffuse large B-cell lymphomas.P53 and the proteasome regulate androgen receptor activity.The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner.A role of the mitotic spindle checkpoint in the cellular response to DNA replication stress
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Prospective therapeutic applications of p53 inhibitors.
@ast
Prospective therapeutic applications of p53 inhibitors.
@en
type
label
Prospective therapeutic applications of p53 inhibitors.
@ast
Prospective therapeutic applications of p53 inhibitors.
@en
prefLabel
Prospective therapeutic applications of p53 inhibitors.
@ast
Prospective therapeutic applications of p53 inhibitors.
@en
P1476
Prospective therapeutic applications of p53 inhibitors.
@en
P2093
Andrei V Gudkov
Elena A Komarova
P304
P356
10.1016/J.BBRC.2005.03.153
P407
P577
2005-06-01T00:00:00Z