Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.
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Natural compounds as modulators of NADPH oxidasesSinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2-ARE PathwaySmall-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.NADPH oxidase as a therapeutic target in Alzheimer's disease.MAPK signaling mediates sinomenine hydrochloride-induced human breast cancer cell death via both reactive oxygen species-dependent and -independent pathways: an in vitro and in vivo study.Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agentsNeuronal apoptosis and inflammatory responses in the central nervous system of a rabbit treated with Shiga toxin-2Antinociceptive effects of sinomenine in a rat model of neuropathic pain.Sinomenine sensitizes gastric cancer cells to 5-fluorouracil in vitro and in vivoCooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinomaSinomenine inhibits microglial activation by Aβ and confers neuroprotection.Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels.Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidaseReactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy.NADPH oxidases: novel therapeutic targets for neurodegenerative diseasesCritical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegenerationbeta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway.Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activationSinomenine inhibits A549 human lung cancer cell invasion by mediating the STAT3 signaling pathway.Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidaseSinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice.Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia.Sinomenine hydrochloride inhibits breast cancer metastasis by attenuating inflammation-related epithelial-mesenchymal transition and cancer stemness.Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury.HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats.Recent developments in the inhibitors of neuroinflammation and neurodegeneration: inflammatory oxidative enzymes as a drug target.Diabetes is an inflammatory disease: evidence from traditional Chinese medicines.Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors.Sinomenium acutum: a review of chemistry, pharmacology, pharmacokinetics, and clinical use.Herbal medicines for ischemic stroke: combating inflammation as therapeutic targets.NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease.The Antioxidant Effects of Thymoquinone in Activated BV-2 Murine Microglial Cells.Phytochemicals in Ischemic Stroke.Modulators of microglial activation and polarization after intracerebral haemorrhage.Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes.Sinomenine Hydrochloride Inhibits Human Glioblastoma Cell Growth through Reactive Oxygen Species Generation and Autophagy-Lysosome Pathway Activation: An In Vitro and In Vivo Study.Sinomenine Protects PC12 Neuronal Cells against H2O2-induced Cytotoxicity and Oxidative Stress via a ROS-dependent Up-regulation of Endogenous Antioxidant System.Effect of sinomenine hydrochloride on radiosensitivity of esophageal squamous cell carcinoma cells.Serum proteomic analysis of the anti‑arthritic effects of sinomenine on rats with collagen‑induced arthritis.
P2860
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P2860
Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Sinomenine, a natural dextroro ...... n of microglial NADPH oxidase.
@ast
Sinomenine, a natural dextroro ...... n of microglial NADPH oxidase.
@en
type
label
Sinomenine, a natural dextroro ...... n of microglial NADPH oxidase.
@ast
Sinomenine, a natural dextroro ...... n of microglial NADPH oxidase.
@en
prefLabel
Sinomenine, a natural dextroro ...... n of microglial NADPH oxidase.
@ast
Sinomenine, a natural dextroro ...... n of microglial NADPH oxidase.
@en
P2093
P2860
P356
P1476
Sinomenine, a natural dextroro ...... on of microglial NADPH oxidase
@en
P2093
Belinda Wilson
Patrick M Flood
P2860
P2888
P356
10.1186/1742-2094-4-23
P577
2007-09-19T00:00:00Z
P5875
P6179
1037005121