Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.
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Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acidsSystematic review: potential preventive effects of statins against oesophageal adenocarcinomaA novel classification of lung cancer into molecular subtypesKnockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway.Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicityMetabolic reprogramming and epithelial-to-mesenchymal transition in cancer.Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibitionATP citrate lyase mediates resistance of colorectal cancer cells to SN38.Statin use and risk of lung cancer: a meta-analysis of observational studies and randomized controlled trials.Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer.Signalling mechanisms regulating phenotypic changes in breast cancer cells.Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition.ATP citrate lyase expression is associated with advanced stage and prognosis in gastric adenocarcinoma.Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis.Statin improves survival in patients with EGFR-TKI lung cancer: A nationwide population-based study.The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathwaysmiR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation.Exploitation of pleiotropic actions of statins by using tumour-targeted delivery systems.Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.Fisetin suppresses ADAM9 expression and inhibits invasion of glioma cancer cells through increased phosphorylation of ERK1/2.Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer.ATP citrate lyase knockdown impacts cancer stem cells in vitro.ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic SwitchThe effect of statins on survival in patients with stage IV lung cancer.RETRACTED ARTICLE: Casticin inhibits epithelial-mesenchymal transition of EBV-infected human retina pigmental epithelial cells through the modulation of intracellular lipogenesis.Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism.Acyl-CoA synthetase short-chain family member 2 (ACSS2) is regulated by SREBP-1 and plays a role in fatty acid synthesis in caprine mammary epithelial cells.Prostate cancer diagnosis and characterization with mass spectrometry imaging.ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway.MiR-22 down-regulates the proto-oncogene ATP citrate lyase to inhibit the growth and metastasis of breast cancer.Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin
P2860
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P2860
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Inhibition of lung cancer grow ...... -3-kinase (PI3K)/AKT pathways.
@ast
Inhibition of lung cancer grow ...... -3-kinase (PI3K)/AKT pathways.
@en
type
label
Inhibition of lung cancer grow ...... -3-kinase (PI3K)/AKT pathways.
@ast
Inhibition of lung cancer grow ...... -3-kinase (PI3K)/AKT pathways.
@en
prefLabel
Inhibition of lung cancer grow ...... -3-kinase (PI3K)/AKT pathways.
@ast
Inhibition of lung cancer grow ...... -3-kinase (PI3K)/AKT pathways.
@en
P2093
P2860
P356
P1476
Inhibition of lung cancer grow ...... -3-kinase (PI3K)/AKT pathways.
@en
P2093
Atsuo T Sasaki
Jun-ichi Hanai
Nathaniel Doro
Pankaj Seth
Susumu Kobayashi
Vikas P Sukhatme
P2860
P304
P356
10.1002/JCP.22895
P577
2012-04-01T00:00:00Z