Activation of STIM1-Orai1 involves an intramolecular switching mechanism.
about
STIM1 couples to ORAI1 via an intramolecular transition into an extended conformationA protease-independent function for SPPL3 in NFAT activationRapid and orthogonal logic gating with a gibberellin-induced dimerization systemSTIM proteins: dynamic calcium signal transducersStructural aspects of calcium-release activated calcium channel functionThe STIM1/Orai signaling machineryMolecular regulation of CRAC channels and their role in lymphocyte functionStore-operated Orai channels: structure and functionStructural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)The inhibitory helix controls the intramolecular conformational switching of the C-terminus of STIM1STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entryDiseases caused by mutations in ORAI1 and STIM1Di-arginine signals and the K-rich domain retain the Ca²⁺ sensor STIM1 in the endoplasmic reticulumInside-out Ca(2+) signalling prompted by STIM1 conformational switch.Initial activation of STIM1, the regulator of store-operated calcium entryRedox regulation of store-operated Ca2+ entryComprehensive analysis and identification of the human STIM1 domains for structural and functional studiesConformational Changes in the Orai1 C-Terminus Evoked by STIM1 BindingSingle-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions.Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis.A dominant STIM1 mutation causes Stormorken syndrome.Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.Sequential Steps of CRAC Channel Activation.Remodelling of the endoplasmic reticulum during store-operated calcium entry.cAMP induces stromal interaction molecule 1 (STIM1) puncta but neither Orai1 protein clustering nor store-operated Ca2+ entry (SOCE) in islet cells.Temperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expressionPotent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs.Molecular determinants within N terminus of Orai3 protein that control channel activation and gating.Local cytosolic Ca2+ elevations are required for stromal interaction molecule 1 (STIM1) de-oligomerization and termination of store-operated Ca2+ entryStore-operated calcium channels: new perspectives on mechanism and function.The dynamic complexity of the TRPC1 channelosome.Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activationStore-operated calcium entry: Mechanisms and modulation.Hypoxia-induced acidosis uncouples the STIM-Orai calcium signaling complexAlternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channelsRegulation of store-operated calcium entry during cell division.Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message.Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunctionSTIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain.
P2860
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P2860
Activation of STIM1-Orai1 involves an intramolecular switching mechanism.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Activation of STIM1-Orai1 involves an intramolecular switching mechanism.
@ast
Activation of STIM1-Orai1 involves an intramolecular switching mechanism.
@en
type
label
Activation of STIM1-Orai1 involves an intramolecular switching mechanism.
@ast
Activation of STIM1-Orai1 involves an intramolecular switching mechanism.
@en
prefLabel
Activation of STIM1-Orai1 involves an intramolecular switching mechanism.
@ast
Activation of STIM1-Orai1 involves an intramolecular switching mechanism.
@en
P2860
P1433
P1476
Activation of STIM1-Orai1 involves an intramolecular switching mechanism
@en
P2093
Isabel Martín Manjarrés
Peter Varnai
P2860
P356
10.1126/SCISIGNAL.2001122
P577
2010-11-16T00:00:00Z