CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. - Wikidata - awgldk - TriplyDB

CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

http://www.wikidata.org/entity/Q36137576

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Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation CD47 deficiency in tumor stroma promotes tumor progression by enhancing angiogenesis.Engulfment signals and the phagocytic machinery for apoptotic cell clearance.Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors.Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society December 7-10, 2015, San Diego, CA, USA.A fully human anti-CD47 blocking antibody with therapeutic potential for cancer HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response.The oncolytic peptide LTX-315 triggers immunogenic cell death.Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?Durable antitumor responses to CD47 blockade require adaptive immune stimulation.Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation.CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy.Future perspectives in melanoma research : Meeting report from the "Melanoma Bridge". Napoli, December 1st-4th 2015.Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma.Myeloid Cell Origins, Differentiation, and Clinical Implications.The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.Is CD47 an innate immune checkpoint for tumor evasion?Integrating conventional and antibody-based targeted anticancer treatment into immunotherapy cGAS is essential for the antitumor effect of immune checkpoint blockade.Targeting CD47: the achievements and concerns of current studies on cancer immunotherapy.Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways Significance of CD47 expression in gastric cancer.CTLA-4 Limits Anti-CD20-Mediated Tumor Regression.An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection.Immune suppressive mechanisms in the tumor microenvironment.Mechanisms of Immune Tolerance in Leukemia and Lymphoma.Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies.Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond.Unravelling the biology of SCLC: implications for therapy.Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps.The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer.cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling.TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.Hematopoietic stem cell transplantation and cellular therapy.Programmed Cell Death and Inflammation: Winter Is Coming.Localized CD47 blockade enhances immunotherapy for murine melanoma.

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P2860

CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

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Nature Medicine

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.

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P2093

Hairong Xu

http://www.w3.org/2001/XMLSchema#string

Hua Peng

http://www.w3.org/2001/XMLSchema#string

Justin Kline

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Kyle Cron

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Liufu Deng

http://www.w3.org/2001/XMLSchema#string

Meng Michelle Xu

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William A Frazier

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Xiaojuan Liu

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Yang Pu

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Yang-Xin Fu

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P2860

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

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10.1038/NM.3931

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10

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4598283

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