Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides - Wikidata - awgldk - TriplyDB

Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

http://www.wikidata.org/entity/Q36141838

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Evolution and dynamics of pancreatic cancer progression Clonal evolution in hematological malignancies and therapeutic implications Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms.SF3B1 mutations in chronic lymphocytic leukemia.The myeloma stem cell concept, revisited: from phenomenology to operational terms Expression of GITR Enhances Multiple Myeloma Cell Sensitivity to Bortezomib Consolidation in multiple myeloma - current status and perspectives SubcloneSeeker: a computational framework for reconstructing tumor clone structure for cancer variant interpretation and prioritization.The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine A Phase II Trial of AZD6244 (Selumetinib, ARRY-142886), an Oral MEK1/2 Inhibitor, in Relapsed/Refractory Multiple Myeloma TALEN-mediated genetic tailoring as a tool to analyze the function of acquired mutations in multiple myeloma cells The varied distribution and impact of RAS codon and other key DNA alterations across the translocation cyclin D subgroups in multiple myeloma TPL2 kinase regulates the inflammatory milieu of the myeloma niche Implications of heterogeneity in multiple myeloma.Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group.Serial exome analysis of disease progression in premalignant gammopathies.Minor clone provides a reservoir for relapse in multiple myeloma Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms.Crosstalk between microRNA30a/b/c/d/e-5p and the canonical Wnt pathway: implications for multiple myeloma therapy Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: a review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease.Cancer heterogeneity: implications for targeted therapeutics.Quantification of clonal circulating plasma cells in relapsed multiple myeloma Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia Whole-exome sequencing of primary plasma cell leukemia discloses heterogeneous mutational patterns.Differential and limited expression of mutant alleles in multiple myeloma.Cutting edge genomics reveal new insights into tumour development, disease progression and therapeutic impacts in multiple myeloma.How I treat smoldering multiple myeloma.canEvolve: a web portal for integrative oncogenomics.Frequent occurrence of highly expanded but unrelated B-cell clones in patients with multiple myeloma.New insights, recent advances, and current challenges in the biological treatment of multiple myeloma.Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells.A one-page summary report of genome sequencing for the healthy adult Genetics of multiple myeloma: another heterogeneity level?BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis Single-molecule analysis reveals widespread structural variation in multiple myeloma.Clonal competition with alternating dominance in multiple myeloma.Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

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Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides

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Ahmet Kurdoglu

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Alexis Christoforides

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Chang-Xin Shi

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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Initial genome sequencing and analysis of multiple myeloma

A method and server for predicting damaging missense mutations

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

Integrative genomics viewer

MutationTaster evaluates disease-causing potential of sequence alterations

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