BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
about
High-quality NMR structure of human anti-apoptotic protein domain Mcl-1(171-327) for cancer drug designStructure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).Induction of apoptosis by diterpenes from the soft coral Xenia elongata.Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells.Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.Apoptosis-inducing galactolipids from a cultured marine diatom, Phaeodactylum tricornutumTargeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosisEGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells.Serum and antibodies of glaucoma patients lead to changes in the proteome, especially cell regulatory proteins, in retinal cells.PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes.NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.Bcl-2 family in inter-organelle modulation of calcium signaling; roles in bioenergetics and cell survival.Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondriaConversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain.Death by association: BH3 domain-only proteins and liver injury.Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activationMechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis.The antiapoptotic role of pregnane X receptor in human colon cancer cells.Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress.Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status.Metabolic catastrophe as a means to cancer cell death.Myeloid cell leukemia-1 as a therapeutic target.Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse modelAlteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.The role of TRAIL death receptors in the treatment of hematological malignancies.Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses.EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis.Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide.A novel role for proline- and acid-rich basic region leucine zipper (PAR bZIP) proteins in the transcriptional regulation of a BH3-only proapoptotic gene.Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells.Anti-Tumor Effects of Bak-Proteoliposomes against Glioblastoma.Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines.In vitro antitumor mechanism of a novel cyclin-dependent kinase inhibitor CDKI-83.An agonistic monoclonal antibody against DR5 induces ROS production, sustained JNK activation and Endo G release in Jurkat leukemia cells.Gamma irradiation of human leukaemic cells HL-60 and MOLT-4 induces decrease in Mcl-1 and Bid, release of cytochrome c, and activation of caspase-8 and caspase-9.Bcl-2 modulation to activate apoptosis in prostate cancer.Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist.
P2860
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P2860
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
@ast
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
@en
type
label
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
@ast
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
@en
prefLabel
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
@ast
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
@en
P356
P1433
P1476
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis.
@en
P2093
Céline Gélinas
P304
P356
10.1101/GAD.1326205
P50
P577
2005-06-01T00:00:00Z