Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival. - Wikidata - awgldk - TriplyDB

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

http://www.wikidata.org/entity/Q33797357

about

JAK2V617F drives Mcl-1 expression and sensitizes hematologic cell lines to dual inhibition of JAK2 and Bcl-xL.A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis.Identification of myeloproliferative neoplasm drug agents via predictive simulation modeling: assessing responsiveness with micro-environment derived cytokines.Thrombosis in myeloproliferative neoplasms with JAK2V617F mutation.Apoptosis deregulation in myeloproliferative neoplasms.Bcl-2 proteins in development, health, and disease of the hematopoietic system.Dysregulation of BCL-2 family proteins by leukemia fusion genes.Resveratrol selectively induces apoptosis in malignant cells with the JAK2V617F mutation by inhibiting the JAK2 pathway.Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2.

P2860

Q35579660-F54FF13D-30C2-4EB2-BD98-68D7ECC83C28 Q35613434-313AAB96-E7F0-4FBC-9F6A-02AC0600C8FD Q35818531-99F94378-875F-437D-9C60-9B73FF226FC1 Q37392623-DD06AF7A-8A32-4882-8E1D-D6490227163A Q38028927-AD719C03-5784-452B-AD02-0EB69A5B07EC Q38184437-E0EA7408-BD82-43E7-82BF-D5DD3B8B4C9B Q38735628-B55A94EA-0163-4020-85B4-1A23DCFDCECB Q39440247-954DA079-9928-4E6B-A0B8-75BB266BEE01 Q55042835-F36F6E49-55EB-4C91-AA4B-B6F520CF8E29 Q55311942-41E3D30B-D697-4D66-92B6-8BFB8EA32433

P2860

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

http://www.wikidata.org/entity/Q33797357

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

@ast

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

@en

type

label

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

@ast

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

@en

prefLabel

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

@ast

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

@en

P1433

Q33797357-C1F185C5-024C-474A-90E6-5EF0CF23CC30

P1476

Q33797357-6DDF7804-212C-4444-B4E2-23F672DA96C6

P2093

Q33797357-0315CE32-E37B-4ACD-A8B4-99B1EABABEB7

Q33797357-1DC90F71-3459-4033-9BBC-BA1080677445

Q33797357-37E18950-290F-4771-8C59-83BEEB27AA05

Q33797357-4EED84C8-6518-48DA-B7F7-D69CFA8D73DE

Q33797357-A7D0174F-53B6-4994-8A16-371D6C9F0858

P2860

Q33797357-0143C3F3-AB99-4013-9213-7DE8EA2968A0

Q33797357-0262C172-C806-4308-B866-1043687A1F7D

Q33797357-0381343E-2AF7-462A-9810-608CE995C765

Q33797357-0B86B9B6-8572-4CEF-9923-D3E68BAF5507

Q33797357-0DF5DACB-95FE-43BB-8B9A-476936A159E0

Q33797357-18D48488-1DFF-49DD-8CA1-7774C35A0C44

Q33797357-1B79BC97-B4B7-4A82-943D-2956D77D0906

Q33797357-1D40B7F2-535B-4C50-BED7-02C026CE4EAA

Q33797357-1E5055E9-89B6-4083-BE5B-E10F7DD501FF

Q33797357-398248E6-2637-4CA8-BDE1-D3EE8D1CCEF6

P2888

Q33797357-C25EBCF3-C290-4D75-9EB5-E6A2A52634CB

P304

Q33797357-8EAB7AAD-189B-41F6-9E0E-3C4524F958D4

P31

Q33797357-4E141653-22CE-42A0-944C-33429D34523B

P356

Q33797357-68670763-0310-4ECD-A5E5-6DD2422B4118

P407

Q33797357-E4847117-FC80-4C82-BC61-09BD41E770A2

P478

Q33797357-71636CD3-FF1B-454D-BEBC-1A9E2B276A04

P577

Q33797357-896A833E-1512-436F-A057-CF4308B7C52E

P5875

Q33797357-161E4CE7-1B49-46F2-84F6-AA01EFF8A8BB

P6179

Q33797357-C5F4F0CA-F7F0-47CF-992F-2545E4F344AF

P698

Q33797357-22E46723-E2EF-41C4-BAF5-B4CDAA595317

P932

Q33797357-45A97115-3185-4C4C-8428-2F6D6E2653A1

P356

1471-2407-11-24

P1433

P1476

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival.

@en

P2093

Daniel A Guthy

http://www.w3.org/2001/XMLSchema#string

Joëlle Rubert

http://www.w3.org/2001/XMLSchema#string

Rita Andraos

http://www.w3.org/2001/XMLSchema#string

Thomas Radimerski

http://www.w3.org/2001/XMLSchema#string

Zhiyan Qian

http://www.w3.org/2001/XMLSchema#string

P2860

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

The Bcl-2 apoptotic switch in cancer development and therapy

Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors

Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805

Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

P2888

1471-2407-11-24

P304

24

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1186/1471-2407-11-24

http://www.w3.org/2001/XMLSchema#string

P407

P478

11

http://www.w3.org/2001/XMLSchema#string

P577

2011-01-19T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

49767356

http://www.w3.org/2001/XMLSchema#string

P6179

1008111456

http://www.w3.org/2001/XMLSchema#string

P698

21247487

http://www.w3.org/2001/XMLSchema#string

P932

3037340

http://www.w3.org/2001/XMLSchema#string