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Illuminating the mechanistic roles of enzyme conformational dynamics

Illuminating the mechanistic roles of enzyme conformational dynamics

http://www.wikidata.org/entity/Q36156767

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Many local motions cooperate to produce the adenylate kinase conformational transition Coarse-grained description of protein internal dynamics: an optimal strategy for decomposing proteins in rigid subunits Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins Hydrogen bond dynamics in membrane protein function Cooperativity in monomeric enzymes with single ligand-binding sites Allosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulations Complex intramolecular mechanics of G-actin--an elastic network study An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal Minimum free energy path of ligand-induced transition in adenylate kinase Allostery in the ferredoxin protein motif does not involve a conformational switch Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing Binding leverage as a molecular basis for allosteric regulation Thermal adaptation of conformational dynamics in ribonuclease H Correlated inter-domain motions in adenylate kinase Path Similarity Analysis: A Method for Quantifying Macromolecular Pathways Ligand Docking to Intermediate and Close-To-Bound Conformers Generated by an Elastic Network Model Based Algorithm for Highly Flexible Proteins Single Molecule Analysis Research Tool (SMART): an integrated approach for analyzing single molecule data The role of dynamic conformational ensembles in biomolecular recognition Mining electron density for functionally relevant protein polysterism in crystal structures.Small- and large-scale conformational changes of adenylate kinase: a molecular dynamics study of the subdomain motion and mechanics Ligand-induced global transitions in the catalytic domain of protein kinase A.Computation of conformational transitions in proteins by virtual atom molecular mechanics as validated in application to adenylate kinase.Zipping and unzipping of adenylate kinase: atomistic insights into the ensemble of open<-->closed transitions.Event detection and sub-state discovery from biomolecular simulations using higher-order statistics: application to enzyme adenylate kinase.ClustENM: ENM-Based Sampling of Essential Conformational Space at Full Atomic Resolution.Urea-Dependent Adenylate Kinase Activation following Redistribution of Structural States.Targeting the active site gate to yield hyperactive variants of 5-aminolevulinate synthase.Conformational transitions in DNA polymerase I revealed by single-molecule FRET.Why does binding of proteins to DNA or proteins to proteins not necessarily spell function?An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling.Dynamic active-site protection by the M. tuberculosis protein tyrosine phosphatase PtpB lid domain.Entropic mechanism of large fluctuation in allosteric transition.Instantaneous normal modes as an unforced reaction coordinate for protein conformational transitions Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency Structural dynamics of bio-macromolecules by NMR: the slowly relaxing local structure approach Fast single-molecule FRET spectroscopy: theory and experiment Structure of an enzyme-derived phosphoprotein recognition domain On the roles of substrate binding and hinge unfolding in conformational changes of adenylate kinase.FRET efficiency distributions of multistate single molecules.Conformational dynamics of a ligand-free adenylate kinase.

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Illuminating the mechanistic roles of enzyme conformational dynamics

http://www.wikidata.org/entity/Q36156767

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Illuminating the mechanistic roles of enzyme conformational dynamics

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Illuminating the mechanistic roles of enzyme conformational dynamics

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Illuminating the mechanistic roles of enzyme conformational dynamics

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Illuminating the mechanistic roles of enzyme conformational dynamics

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Illuminating the mechanistic roles of enzyme conformational dynamics

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Illuminating the mechanistic roles of enzyme conformational dynamics

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Proceedings of the National Academy of Sciences of the United States of America

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Illuminating the mechanistic roles of enzyme conformational dynamics

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Haw Yang

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Jason Brokaw

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Jeffrey A Hanson

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Lucas P Watkins

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Sucharita Bhattacharyya

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P2860

The Database of Macromolecular Motions: new features added at the decade mark.

The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP

Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding

Ancient divergence of long and short isoforms of adenylate kinase: molecular evolution of the nucleoside monophosphate kinase family

Movie of the structural changes during a catalytic cycle of nucleoside monophosphate kinases

Intrinsic dynamics of an enzyme underlies catalysis

The energy landscapes and motions of proteins

Evolutionary relationships and structural mechanisms of AAA+ proteins

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins.

Escherichia coli adenylate kinase dynamics: comparison of elastic network model modes with mode-coupling (15)N-NMR relaxation data.

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18055-18060

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Karl E Duderstadt

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