Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors.
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Targeting the Checkpoint to Kill Cancer CellsPerspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancerMolecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and TreatmentCell cycle checkpoint in cancer: a therapeutically targetable double-edged swordWee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapyCombination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions.Drosophila Cancer Models Identify Functional Differences between Ret Fusions.Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination RepairChemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo.Critical reanalysis of the methods that discriminate the activity of CDK2 from CDK1Evaluation of rucaparib and companion diagnostics in the PARP inhibitor landscape for recurrent ovarian cancer therapy.Translational and clinical implications of the genetic landscape of prostate cancer.Continuous anti-angiogenic therapy after tumor progression in patients with recurrent high-grade epithelial ovarian cancer: phase I trial experience.Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer.Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitorsAn overview of tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer.AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells.Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.CDK4/6 inhibitors sensitize Rb-positive sarcoma cells to Wee1 kinase inhibition through reversible cell cycle arrest.Expression and clinical significance of Wee1 in colorectal cancer.Identification of clinically achievable combination therapies in childhood rhabdomyosarcoma.Unravelling the biology of SCLC: implications for therapy.Cytokinetic effects of Wee1 disruption in pancreatic cancer.Investigational drugs for head and neck cancer.Systemic Treatment Strategies for Patients with Hereditary Breast Cancer Syndromes.Cell Cycle Regulation and Melanoma.The cell cycle checkpoint inhibitors in the treatment of leukemias.Small cell lung cancer: Time to revisit DNA-damaging chemotherapy.HPLC-UV method for simultaneous determination of MK-1775 and AZD-7762 in both acetonitrile-aqueous solution and mouse plasma.Development of Cancer Vaccines Targeting Brachyury, a Transcription Factor Associated with Tumor Epithelial-Mesenchymal Transition.3q26-29 Amplification in head and neck squamous cell carcinoma: a review of established and prospective oncogenes.Advances of small molecule targeting of kinases.Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity.WEE1 inhibition in pancreatic cancer cells is dependent on DNA repair status in a context dependent manner.Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.Mutational status of TP53 defines the efficacy of Wee1 inhibitor AZD1775 in KRAS-mutant non-small cell lung cancer.Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases.
P2860
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P2860
Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Phase I Study of Single-Agent ...... With Refractory Solid Tumors.
@ast
Phase I Study of Single-Agent ...... With Refractory Solid Tumors.
@en
type
label
Phase I Study of Single-Agent ...... With Refractory Solid Tumors.
@ast
Phase I Study of Single-Agent ...... With Refractory Solid Tumors.
@en
prefLabel
Phase I Study of Single-Agent ...... With Refractory Solid Tumors.
@ast
Phase I Study of Single-Agent ...... With Refractory Solid Tumors.
@en
P2093
P2860
P356
P1476
Phase I Study of Single-Agent ...... With Refractory Solid Tumors.
@en
P2093
Alice P Chen
Deborah Wilsker
James H Doroshow
Jennifer Zlott
Jerry Collins
Jiuping Ji
Robert J Kinders
Shivaani Kummar
Tomoko Freshwater
P2860
P304
P356
10.1200/JCO.2014.60.4009
P407
P577
2015-05-11T00:00:00Z