Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors.
about
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeStructure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold MorphingChemotherapy Drug Induced Discoordination of Mitochondrial Life Cycle Detected by Cardiolipin FluctuationATR: an essential regulator of genome integrityOverexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancerRSK2 Binding Models Delineate Key Features for ActivityFunction of a conserved checkpoint recruitment domain in ATRIP proteins.The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.Development of molecular probes for imaging sigma-2 receptors in vitro and in vivo.The σ2 receptor: a novel protein for the imaging and treatment of cancer.Probing the probes: fitness factors for small molecule tools.Palbociclib (PD 0332991) : targeting the cell cycle machinery in breast cancer.Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulatorsXanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugsAnaphase catastrophe is a target for cancer therapyQuantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1.Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursorsIntegrin beta-8 (ITGB8) silencing reverses gefitinib resistance of human hepatic cancer HepG2/G cell line.Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functionsNovel intestinal splice variants of RNA-binding protein CUGBP2: isoform-specific effects on mitotic catastrophe.Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.Ligand discovery and virtual screening using the program LIDAEUS.Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F.New combination therapies with cell-cycle agentsMolecular targets and mechanisms of radiosensitization using DNA damage response pathways.Tumor suppressor p16(INK4a) inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction.The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity.The molecular genetics of breast cancer and targeted therapyO-desmethylangolensin inhibits the proliferation of human breast cancer MCF-7 cells by inducing apoptosis and promoting cell cycle arrest.Impaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.Targeting cell cycle and hormone receptor pathways in cancer.Measuring and interpreting the selectivity of protein kinase inhibitorsMechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-PlatinMolecular pathways for cancer chemoprevention by dietary phytochemicals.Multistage carcinogenesis process as molecular targets in cancer chemoprevention by epicatechin-3-gallate.Cyclin dependent kinases in cancer: potential for therapeutic intervention.Cell cycle regulation by the intrinsically disordered proteins p21 and p27.The oncogene mcts1Development of anticancer drugs based on the hallmarks of tumor cells.
P2860
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P2860
Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Targeting the cell division cy ...... checkpoint kinase inhibitors.
@ast
Targeting the cell division cy ...... checkpoint kinase inhibitors.
@en
type
label
Targeting the cell division cy ...... checkpoint kinase inhibitors.
@ast
Targeting the cell division cy ...... checkpoint kinase inhibitors.
@en
prefLabel
Targeting the cell division cy ...... checkpoint kinase inhibitors.
@ast
Targeting the cell division cy ...... checkpoint kinase inhibitors.
@en
P1476
Targeting the cell division cy ...... checkpoint kinase inhibitors.
@en
P2093
Ian Collins
Michelle D Garrett
P304
P356
10.1016/J.COPH.2005.04.009
P577
2005-08-01T00:00:00Z