Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.
about
Mechanisms of Hsp90 regulationHsp90: A New Player in DNA Repair?DNA-PK: a dynamic enzyme in a versatile DSB repair pathwayGenotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancerHsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteinsRegulation and function of the human HSP90AA1 geneEndoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase βPersistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine.Collaboration of geldanamycin-activated P70S6K and Hsp70 against beta-amyloid-induced hippocampal apoptosis: an approach to long-term memory and learningHsp90 C-terminal inhibitors exhibit antimigratory activity by disrupting the Hsp90α/Aha1 complex in PC3-MM2 cells.Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAGSafety control for apoptotic irreversibilityTargeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancerA systems biology-based investigation into the pharmacological mechanisms of wu tou tang acting on rheumatoid arthritis by integrating network analysis.ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiationDetection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining.Silencing of Hsp70 intensifies 6-OHDA-induced apoptosis and Hsp90 upregulation in PC12 cells.The Mechanism of Hsp90 ATPase Stimulation by Aha1Regulatory Mechanisms of Hsp90.DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.Insight into glucocorticoid receptor signalling through interactome model analysis.Clinical Evaluation and Biomarker Profiling of Hsp90 Inhibitors.Detecting Posttranslational Modifications of Hsp90.Heat shock proteins and DNA repair mechanisms: an updated overview.Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.The initiator caspase Dronc plays a non-apoptotic role in promoting DNA damage signalling in D. melanogaster.The role of DNA-PK in aging and energy metabolism.Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation.
P2860
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P2860
Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Heat shock protein 90α (HSP90α ...... ry for the apoptotic response.
@ast
Heat shock protein 90α (HSP90α ...... ry for the apoptotic response.
@en
type
label
Heat shock protein 90α (HSP90α ...... ry for the apoptotic response.
@ast
Heat shock protein 90α (HSP90α ...... ry for the apoptotic response.
@en
prefLabel
Heat shock protein 90α (HSP90α ...... ry for the apoptotic response.
@ast
Heat shock protein 90α (HSP90α ...... ry for the apoptotic response.
@en
P2093
P2860
P356
P1476
Heat shock protein 90α (HSP90α ...... ry for the apoptotic response.
@en
P2093
Bradley Scroggins
Jane Trepel
Kurt W Kohn
Leonard Neckers
Stéphanie Solier
Wanping Xu
P2860
P304
12866-12872
P356
10.1073/PNAS.1203617109
P407
P50
P577
2012-07-02T00:00:00Z