CAG expansion induces nucleolar stress in polyglutamine diseases. - Wikidata - awgldk - TriplyDB

CAG expansion induces nucleolar stress in polyglutamine diseases.

CAG expansion induces nucleolar stress in polyglutamine diseases.

http://www.wikidata.org/entity/Q36170710

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Neuroprotective Transcription Factors in Animal Models of Parkinson Disease Nucleolar activity in neurodegenerative diseases: a missing piece of the puzzle?RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Mechanisms of RNA-induced toxicity in CAG repeat disorders New insights into nucleolar structure and function Non-coding RNA in neural function, disease, and aging RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis RNA phase transitions in repeat expansion disorders.A neuroprotective phase precedes striatal degeneration upon nucleolar stress.Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.C9orf72 nucleotide repeat structures initiate molecular cascades of disease.Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models Oligonucleotide-based strategies to combat polyglutamine diseases.Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.The role of the immune system in triplet repeat expansion diseases Structural Insights Reveal the Dynamics of the Repeating r(CAG) Transcript Found in Huntington's Disease (HD) and Spinocerebellar Ataxias (SCAs)Alleviating neurodegeneration in Drosophila models of PolyQ diseases.The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53 Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.The first crystal structures of RNA-PNA duplexes and a PNA-PNA duplex containing mismatches--toward anti-sense therapy against TREDs RNA toxicity in polyglutamine disorders: concepts, models, and progress of research Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases.Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions.PABPN1: molecular function and muscle disease.Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.Structure and Dynamics of RNA Repeat Expansions That Cause Huntington's Disease and Myotonic Dystrophy Type 1.RNA toxicity induced by expanded CAG repeats in Huntington's disease.A link between chromatin condensation mechanisms and Huntington's disease: connecting the dots.Can Human Pluripotent Stem Cell-Derived Cardiomyocytes Advance Understanding of Muscular Dystrophies?Regulation of mRNA Translation by MID1: A Common Mechanism of Expanded CAG Repeat RNAs.Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila.A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases.The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.The nucleolus fine-tunes the orchestration of an early neuroprotection response in neurodegeneration.Expression of expanded CAG transcripts triggers nucleolar stress in Huntington's disease.Non-structural protein 1 of H3N2 influenza A virus induces nucleolar stress via interaction with nucleolin.A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases.Inhibition of autophagy via p53-mediated disruption of ULK1 in a SCA7 polyglutamine disease model.

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P2860

CAG expansion induces nucleolar stress in polyglutamine diseases.

http://www.wikidata.org/entity/Q36170710

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2012 nî lūn-bûn

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name

CAG expansion induces nucleolar stress in polyglutamine diseases.

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CAG expansion induces nucleolar stress in polyglutamine diseases.

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CAG expansion induces nucleolar stress in polyglutamine diseases.

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CAG expansion induces nucleolar stress in polyglutamine diseases.

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CAG expansion induces nucleolar stress in polyglutamine diseases.

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Ho Tsoi

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Ho Yin Edwin Chan

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Kwok-Fai Lau

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Suk-Ying Tsang

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Terrence Chi-Kong Lau

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P2860

p53 has a direct apoptogenic role at the mitochondria

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

The nucleolus under stress

Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis

Streptavidin aptamers: affinity tags for the study of RNAs and ribonucleoproteins

Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I

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