Contrasting models of promiscuous gene expression by thymic epithelium
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Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific AutoantigensTranscriptional regulation by AIRE: molecular mechanisms of central toleranceThymic epithelial cell development and differentiation: cellular and molecular regulationCentral tolerance: learning self-control in the thymusAire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-toleranceLymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation.Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions.Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.Proliferative arrest and rapid turnover of thymic epithelial cells expressing AirePromiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism.Autoimmunity: basic mechanisms and implications in endocrine diseases. Part I.Roadmap to a better therapeutic tumor vaccine.Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiatedAlterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiationLymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.A roadmap for thymic epithelial cell development.Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla.Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development.Medullary thymic epithelial cells, the indispensable player in central tolerance.Which model better fits the role of aire in the establishment of self-tolerance: the transcription model or the maturation model?Thymic stromal cell subsets for T cell development.Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiationIn vitro co-culture systems for studying molecular basis of cellular interaction between Aire-expressing medullary thymic epithelial cells and fresh thymocytesSingle-cell RNA-sequencing resolves self-antigen expression during mTEC development.Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin.
P2860
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P2860
Contrasting models of promiscuous gene expression by thymic epithelium
description
2005 nî lūn-bûn
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2005年の論文
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2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Contrasting models of promiscuous gene expression by thymic epithelium
@ast
Contrasting models of promiscuous gene expression by thymic epithelium
@en
type
label
Contrasting models of promiscuous gene expression by thymic epithelium
@ast
Contrasting models of promiscuous gene expression by thymic epithelium
@en
prefLabel
Contrasting models of promiscuous gene expression by thymic epithelium
@ast
Contrasting models of promiscuous gene expression by thymic epithelium
@en
P2860
P921
P356
P1476
Contrasting models of promiscuous gene expression by thymic epithelium
@en
P2093
Andrew G Farr
Geoffrey O Gillard
P2860
P356
10.1084/JEM.20050976
P407
P577
2005-06-27T00:00:00Z
2005-07-04T00:00:00Z