USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168. - Wikidata - awgldk - TriplyDB

USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.

USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.

http://www.wikidata.org/entity/Q36184372

about

DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets Role of Deubiquitinating Enzymes in DNA Repair Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin.Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis.USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability.USP7 saves RIDDLE for the end.Dual-utility NLS drives RNF169-dependent DNA damage responses.Human CRL4DDB2 ubiquitin ligase preferentially regulates post-repair chromatin restoration of H3K56Ac through recruitment of histone chaperon CAF-1.An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168.Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response.Molecular dynamics simulation reveals the possible druggable of USP7

P2860

Q26741797-68B76F7B-8BDB-43CB-BEC9-D8AE4BA329D4 Q26773800-5101D0C1-AA4C-4143-B631-18719E24069E Q36755008-28F21833-5E99-4053-A4D2-1F83291362B5 Q36951802-3B9DDDB7-D9FF-4F0E-8C89-D9D0483899C1 Q37709246-66F7810B-F319-4274-B6CD-27492BB627BD Q42124232-9B8F3713-38BC-444C-8497-7D94FDD11233 Q42291846-6F6D5366-4630-4D4F-911D-58D39D4DD927 Q47217424-84F82337-BE73-426B-BDCC-85F034395FE3 Q48411490-0A97A503-C32D-4754-AABA-6253E6DCD8F3 Q51351795-BF9095C1-2EBE-4F1B-A273-E08B49041FF6 Q57821066-B3B56CF3-7C2D-4F72-A0B9-B3A2362BB4C1

P2860

USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.

http://www.wikidata.org/entity/Q36184372

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

USP7 deubiquitinase promotes u ...... gnaling by stabilizing RNF168.

@ast

USP7 deubiquitinase promotes u ...... gnaling by stabilizing RNF168.

@en

type

label

USP7 deubiquitinase promotes u ...... gnaling by stabilizing RNF168.

@ast

USP7 deubiquitinase promotes u ...... gnaling by stabilizing RNF168.

@en

prefLabel

USP7 deubiquitinase promotes u ...... gnaling by stabilizing RNF168.

@ast

USP7 deubiquitinase promotes u ...... gnaling by stabilizing RNF168.

@en

P1433

Q36184372-4E7E367B-18D8-4B8F-95F9-8CD79B60D903

P1476

Q36184372-A70377D0-D2EE-44EC-8275-2149C5FAA335

P2093

Q36184372-1476E583-39C9-449A-9A7E-E5D54B6B08A2

Q36184372-3AC0B853-DB07-4A33-943C-1A8B9ADD8D0A

Q36184372-72182B41-DD92-4DA7-8D41-4E439B4C2DF4

Q36184372-E9248E26-F99C-4BFA-947A-83F2115EADF2

Q36184372-F56EF664-F8A5-4B3A-85EB-1C0E3F84443F

P2860

Q36184372-02934D76-E26B-4AD7-BAA0-933ABC265983

Q36184372-130E82D2-75C0-416C-8795-53804F620BD3

Q36184372-13A5E3FE-BB16-4623-8334-1ED8C5C57119

Q36184372-1B954569-7686-49A3-A155-F62E9B63D50B

Q36184372-1BD9BBF8-5114-459F-96EF-B67A518C7D1B

Q36184372-1EE8AC1C-8AF7-4950-A07E-8CF6AD9B793E

Q36184372-1F25E1DF-07EE-4C21-A6E9-C885E3DD6A6D

Q36184372-20F7A8E3-C7D6-4592-B200-58300CDD8393

Q36184372-25786811-E2B4-4727-937F-6CDFC525354E

Q36184372-25FCCF22-94ED-46C7-B33A-603CA9AC69A4

P304

Q36184372-B4B2E5A2-BFCC-4378-A74C-D69F744C3C40

P31

Q36184372-BF271662-185D-4539-B8E8-7E27C7DEF9D3

P356

Q36184372-C60012E2-E1E9-44D8-AD23-BA834A768F17

P433

Q36184372-0DB87F56-721D-4141-84B6-B3C18D96A971

P478

Q36184372-12B3165D-9FEC-407C-95C3-609307279A60

P577

Q36184372-414F6558-D7EB-45A2-9867-ED486C2610B4

P698

Q36184372-DFB26BCA-6FC5-4E3A-BAFC-1237F1D19022

P921

Q36184372-0117895D-EC89-48A1-9E04-45D8F67331DF

P932

Q36184372-D8DE826B-A63A-433A-8A75-A574416E2DCC

P356

15384101.2015.1007785

P1433

P1476

USP7 deubiquitinase promotes u ...... gnaling by stabilizing RNF168.

@en

P2093

Altaf A Wani

http://www.w3.org/2001/XMLSchema#string

Gulzar Wani

http://www.w3.org/2001/XMLSchema#string

Jinshan He

http://www.w3.org/2001/XMLSchema#string

Nidhi Sharma

http://www.w3.org/2001/XMLSchema#string

Qianzheng Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2

Role of histone H2A ubiquitination in Polycomb silencing

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

P304

1413-1425

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1080/15384101.2015.1007785

http://www.w3.org/2001/XMLSchema#string

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

14

http://www.w3.org/2001/XMLSchema#string

P577

2015-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

25894431

http://www.w3.org/2001/XMLSchema#string

P921

P932

4613370

http://www.w3.org/2001/XMLSchema#string