Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis
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Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin.Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance.TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes.Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β-cell insulin secretion during inflammation.SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia.Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on β-Cell Function.TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.Beta-cell hubs maintain Ca oscillations in human and mouse islet simulations
P2860
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P2860
Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@ast
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@en
type
label
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@ast
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@en
prefLabel
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@ast
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@en
P2093
P2860
P356
P1433
P1476
Type 2 Diabetes-Associated K+ ...... etion, and Glucose Homeostasis
@en
P2093
David A Jacobson
David R Powell
Imju Jeong
Matthew Dickerson
Nicholas C Vierra
Prasanna K Dadi
P2860
P304
P356
10.2337/DB15-0280
P407
P577
2015-08-03T00:00:00Z