Keap1 degradation by autophagy for the maintenance of redox homeostasis - Wikidata - awgldk - TriplyDB

Keap1 degradation by autophagy for the maintenance of redox homeostasis

Keap1 degradation by autophagy for the maintenance of redox homeostasis

http://www.wikidata.org/entity/Q36187388

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Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress Mitochondria, cholesterol and cancer cell metabolism Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases Autophagy in malignant transformation and cancer progression Redox control of microglial function: molecular mechanisms and functional significance Role of p62/SQSTM1 in liver physiology and pathogenesis Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming p62/SQSTM1 functions as a signaling hub and an autophagy adaptor Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy Aromatase Inhibitor-Mediated Downregulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer Oxidative stress, redox signaling, and autophagy: cell death versus survival Oxidative stress and autophagy: the clash between damage and metabolic needs Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1 The complexity of the Nrf2 pathway: beyond the antioxidant response p62 links autophagy and Nrf2 signaling Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum Boning up on autophagy: the role of autophagy in skeletal biology Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice Two-colored fluorescence correlation spectroscopy screening for LC3-P62 interaction inhibitors.Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin.Reductive potential - a savior turns stressor in protein aggregation cardiomyopathy p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB.Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells.Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates.Redox regulation of autophagy in healthy brain and neurodegeneration.The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells Crosstalk between Nrf2 and Notch signaling.Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS.Lysosomes: Regulators of autophagy in the retinal pigmented epithelium.Oxidative stress and autophagy: crucial modulators of kidney injury

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P2860

Keap1 degradation by autophagy for the maintenance of redox homeostasis

http://www.wikidata.org/entity/Q36187388

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

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2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Keap1 degradation by autophagy for the maintenance of redox homeostasis

@ast

Keap1 degradation by autophagy for the maintenance of redox homeostasis

@en

type

label

Keap1 degradation by autophagy for the maintenance of redox homeostasis

@ast

Keap1 degradation by autophagy for the maintenance of redox homeostasis

@en

prefLabel

Keap1 degradation by autophagy for the maintenance of redox homeostasis

@ast

Keap1 degradation by autophagy for the maintenance of redox homeostasis

@en

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PNAS.1121572109

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Keap1 degradation by autophagy for the maintenance of redox homeostasis

@en

P2093

Hozumi Motohashi

http://www.w3.org/2001/XMLSchema#string

Keiko Taguchi

http://www.w3.org/2001/XMLSchema#string

Masayuki Yamamoto

http://www.w3.org/2001/XMLSchema#string

Michiaki Unno

http://www.w3.org/2001/XMLSchema#string

Nanako Fujikawa

http://www.w3.org/2001/XMLSchema#string

Takaaki Akaike

http://www.w3.org/2001/XMLSchema#string

Tetsuro Ishii

http://www.w3.org/2001/XMLSchema#string

P2860

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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13561-13566

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scholarly article

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10.1073/PNAS.1121572109

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P433

34

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109

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Masaaki Komatsu

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2012-08-07T00:00:00Z

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230633346

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22872865

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3427110

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