Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
about
New antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitorsHigh-throughput identification of inhibitors of human mitochondrial peptide deformylase.Solvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase.Approaches to the simultaneous inactivation of metallo- and serine-beta-lactamases.Investigational antimicrobial agents of 2013.Crystal structure of 2-chloro-1-(3-methyl-2,6-di-phenyl-piperidin-1-yl)ethanone.Transcriptional and Phenotypic Characterization of Novel Spx-Regulated Genes in Streptococcus mutans.Drug forecast - the peptide deformylase inhibitors as antibacterial agents.Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors.Effect of H2 blockade and food on single-dose pharmacokinetics of GSK1322322, a peptide deformylase inhibitor antibacterial.Metal-dependent gene regulation in the causative agent of Lyme disease.In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models.Reactions of N-benzyloxycarbamate derivatives with stabilized carbon nucleophiles: a new synthetic approach to polyhydroxamic acids and other hydroxamate-containing mixed ligand systemsPeptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery.Penetration of GSK1322322 into epithelial lining fluid and alveolar macrophages as determined by bronchoalveolar lavageDesign of clinically useful macromolecular iron chelators.Expression, purification, and activity assay of peptide deformylase from Escherichia coli and Staphylococcus aureus.Single-dose safety, tolerability, and pharmacokinetics of the antibiotic GSK1322322, a novel peptide deformylase inhibitor.Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicityr-2,c-6-Di-phenyl-piperidine.Proteomic study of peptide deformylase inhibition in Streptococcus pneumoniae and Staphylococcus aureus.Ligand and Structure-Based Approaches for the Identification of Peptide Deformylase Inhibitors as Antibacterial Drugs.A profiling platform for the identification of selective metalloprotease inhibitors.Asymmetric synthesis of tetrahydropyridines via an organocatalytic one-pot multicomponent Michael/aza-Henry/cyclization triple domino reaction.A highly efficient access to enantiopure tetrahydropyridines: dual-organocatalyst-promoted asymmetric cascade reaction.Synthesis and in-vitro antimicrobial evaluation of a high-affinity iron chelator in combination with chloramphenicol.Design and synthesis of 4'-((5-benzylidene-2,4-dioxothiazolidin-3-yl)methyl)biphenyl-2-carbonitrile analogs as bacterial peptide deformylase inhibitors.Pharmacokinetics and unexpected safety issues of LBM415, a novel oral peptide deformylase inhibitor.High-throughput analysis of Yersinia pseudotuberculosis gene essentiality in optimised in vitro conditions, and implications for the speciation of Yersinia pestis.
P2860
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P2860
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
@ast
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
@en
type
label
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
@ast
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
@en
prefLabel
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
@ast
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
@en
P2093
P356
P1476
Bacterial Peptide deformylase inhibitors: a new class of antibacterial agents.
@en
P2093
P304
P356
10.2174/0929867054367194
P577
2005-01-01T00:00:00Z