Attempts to restore scrapie prion infectivity after exposure to protein denaturants
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Transmission of prionsPrionsElimination of prions by branched polyamines and implications for therapeuticsThe strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of diseasePK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrPStrain-specified relative conformational stability of the scrapie prion proteinPrion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoformDeletion of beta-strand and alpha-helix secondary structure in normal prion protein inhibits formation of its protease-resistant isoform.Quantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfectionThe role of dimerization in prion replicationInactivation of prions by acidic sodium dodecyl sulfateViral particles are required for infection in neurodegenerative Creutzfeldt-Jakob disease.Structure and polymorphism of the mouse prion protein gene.Mimicking dominant negative inhibition of prion replication through structure-based drug design.Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.Using small molecule reagents to selectively modify epitopes based on their conformation.Thermal stability and conformational transitions of scrapie amyloid (prion) protein correlate with infectivity.Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: impact on Rab3a recyclingCopper and the prion protein: methods, structures, function, and diseaseMice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.The role of RNA in mammalian prion protein conversion.Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms.Detection of bovine spongiform encephalopathy-specific PrP(Sc) by treatment with heat and guanidine thiocyanate.Prion protein isoforms, a convergence of biological and structural investigations.The anti-prion activity of Congo red. Putative mechanism.Infectivity of scrapie prions.Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob Disease.Assembly of natural and recombinant prion protein into fibrils.Dehydration of prions on environmentally relevant surfaces protects them from inactivation by freezing and thawing.Protease-resistant and detergent-insoluble prion protein is not necessarily associated with prion infectivity.Reversibility of scrapie inactivation is enhanced by copper.Photo-induced crosslinking of prion protein oligomers and prions.Persistence of Aβ seeds in APP null mouse brain.
P2860
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P2860
Attempts to restore scrapie prion infectivity after exposure to protein denaturants
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1993 nî lūn-bûn
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1993年の論文
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1993年学术文章
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1993年学术文章
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1993年学术文章
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1993年学术文章
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1993年学术文章
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name
Attempts to restore scrapie prion infectivity after exposure to protein denaturants
@ast
Attempts to restore scrapie prion infectivity after exposure to protein denaturants
@en
type
label
Attempts to restore scrapie prion infectivity after exposure to protein denaturants
@ast
Attempts to restore scrapie prion infectivity after exposure to protein denaturants
@en
prefLabel
Attempts to restore scrapie prion infectivity after exposure to protein denaturants
@ast
Attempts to restore scrapie prion infectivity after exposure to protein denaturants
@en
P2093
P2860
P356
P1476
Attempts to restore scrapie prion infectivity after exposure to protein denaturants
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.7.2793
P407
P577
1993-04-01T00:00:00Z