The anti-prion activity of Congo red. Putative mechanism.
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Hot spots in prion protein for pathogenic conversionPharmaceutical and biomedical applications of affinity chromatography: recent trends and developmentsImmobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form.Tetracyclines affect prion infectivity.From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.Inoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival.Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP.Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures.Opposite effects of dextran sulfate 500, the polyene antibiotic MS-8209, and Congo red on accumulation of the protease-resistant isoform of PrP in the spleens of mice inoculated intraperitoneally with the scrapie agent.Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody.Acridine and phenothiazine derivatives as pharmacotherapeutics for prion diseasePrion protein-specific antibodies-development, modes of action and therapeutics applicationPrion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures.Experimental treatments for human transmissible spongiform encephalopathies: is there a role for pentosan polysulfate?Transmission of prion disease.The transmissible spongiform encephalopathies: pathogenic mechanisms and strategies for therapeutic intervention.Amyloidogenesis: historical and modern observations point to heparan sulfate proteoglycans as a major culprit.Emerging therapeutic agents for transmissible spongiform encephalopathies: a review.Mimicking dominant negative inhibition of prion replication through structure-based drug design.Recent advances in prion chemotherapeutics.Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.Mechanistic insights into the cure of prion disease by novel antiprion compoundsAn overview of transmissible spongiform encephalopathies.Therapeutic approaches for prion disorders.Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion proteinHormesis and medicine.Guanidine hydrochloride blocks a critical step in the propagation of the prion-like determinant [PSI(+)] of Saccharomyces cerevisiae.Therapeutic interventions ameliorating prion disease.Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases.2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion diseaseModulation of prion protein oligomerization, aggregation, and beta-sheet conversion by 4,4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS).Exploring Anti-Prion Glyco-Based and Aromatic Scaffolds: A Chemical Strategy for the Quality of Life.Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231.Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead CompoundsValproic acid treatment results in increased accumulation of prion proteins.Pharmacokinetics and distribution of sodium 3,4-diaminonaphthalene-1-sulfonate, a Congo Red derivative active in inhibiting PrP(res) replication.PrPSc incorporation to cells requires endogenous glycosaminoglycan expression.Congo red populates partially unfolded states of an amyloidogenic protein to enhance aggregation and amyloid fibril formation.Targeting of Disordered Proteins by Small Molecules in Neurodegenerative Diseases.
P2860
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P2860
The anti-prion activity of Congo red. Putative mechanism.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
The anti-prion activity of Congo red. Putative mechanism.
@en
type
label
The anti-prion activity of Congo red. Putative mechanism.
@en
prefLabel
The anti-prion activity of Congo red. Putative mechanism.
@en
P2093
P2860
P356
P1476
The anti-prion activity of Congo red. Putative mechanism.
@en
P2093
P2860
P304
P356
10.1074/JBC.273.6.3484
P407
P577
1998-02-01T00:00:00Z