Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
about
Islet biology, the CDKN2A/B locus and type 2 diabetes risk.Adult tissue sources for new β cells.The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate.Human β-cell regeneration: progress, hurdles, and controversy.Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms.Young capillary vessels rejuvenate aged pancreatic isletsIn vitro differentiation and expansion of human pluripotent stem cell-derived pancreatic progenitors.Recent progress in studies of factors that elicit pancreatic β-cell expansionConnective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in miceStructural similarities and differences between the human and the mouse pancreas.A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells.Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism.PNA lectin for purifying mouse acinar cells from the inflamed pancreas.The role of aging upon β cell turnover.Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet TransplantationHow to make a functional β-cellNeurogenin3 activation is not sufficient to direct duct-to-beta cell transdifferentiation in the adult pancreas.G0-G1 transition and the restriction point in pancreatic β-cells in vivo.Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes.Insulin-positive, Glut2-low cells present within mouse pancreas exhibit lineage plasticity and are enriched within extra-islet endocrine cell clusters.Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits.Individual Variation in Conditional β Cell Ablation Mice Contributes Significant Biases in Evaluating β Cell Functional Recovery.Systemic regulation of the age-related decline of pancreatic β-cell replication.Glucose regulates rat beta cell number through age-dependent effects on beta cell survival and proliferation.Neonatal pancreatic pericytes support β-cell proliferation.β-Cell dedifferentiation, reduced duct cell plasticity, and impaired β-cell mass regeneration in middle-aged rats.Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes.Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice.
P2860
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P2860
Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
@ast
Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
@en
type
label
Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
@ast
Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
@en
prefLabel
Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
@ast
Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
@en
P2093
P2860
P356
P1476
Pancreatic beta cells in very old mice retain capacity for compensatory proliferation.
@en
P2093
Benjamin Glaser
Joseph Grimsby
Miri Stolovich-Rain
P2860
P304
27407-27414
P356
10.1074/JBC.M112.350736
P407
P577
2012-06-27T00:00:00Z