Pathways involved in targeting and secretion of a lysosomal enzyme in Dictyostelium discoideum.
about
Dictyostelium LvsB mutants model the lysosomal defects associated with Chediak-Higashi syndrome.The AP-1 clathrin-adaptor is required for lysosomal enzymes sorting and biogenesis of the contractile vacuole complex in Dictyostelium cellsCathepsin B: association with plasma membrane in metastatic tumors.Lysosomal enzymes in Dictyostelium discoideum are transported to lysosomes at distinctly different rates.Inhibition of early but not late proteolytic processing events leads to the missorting and oversecretion of precursor forms of lysosomal enzymes in Dictyostelium discoideum.A Dictyostelium discoideum mutant that missorts and oversecretes lysosomal enzyme precursors is defective in endocytosisDeveloping Dictyostelium cells contain the lysosomal enzyme alpha-mannosidase in a secretory granule.Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organizationClathrin heavy chain functions in sorting and secretion of lysosomal enzymes in Dictyostelium discoideum.The lysosomal proenzyme receptor that binds procathepsin L to microsomal membranes at pH 5 is a 43-kDa integral membrane protein.The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum.The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility.A role for a Rab4-like GTPase in endocytosis and in regulation of contractile vacuole structure and function in Dictyostelium discoideumEvidence for a recycling role for Rab7 in regulating a late step in endocytosis and in retention of lysosomal enzymes in Dictyostelium discoideum.Protease trafficking in two primitive eukaryotes is mediated by a prodomain protein motif.Isolation and characterization of a plasma membrane calcium pump from Dictyostelium discoideum.The prespore vesicles of Dictyostelium discoideum. Purification, characterization, and developmental regulation.Production and secretion of recombinant proteins in Dictyostelium discoideum.
P2860
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P2860
Pathways involved in targeting and secretion of a lysosomal enzyme in Dictyostelium discoideum.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
Pathways involved in targeting ...... e in Dictyostelium discoideum.
@ast
Pathways involved in targeting ...... e in Dictyostelium discoideum.
@en
type
label
Pathways involved in targeting ...... e in Dictyostelium discoideum.
@ast
Pathways involved in targeting ...... e in Dictyostelium discoideum.
@en
prefLabel
Pathways involved in targeting ...... e in Dictyostelium discoideum.
@ast
Pathways involved in targeting ...... e in Dictyostelium discoideum.
@en
P2093
P2860
P356
P1476
Pathways involved in targeting ...... e in Dictyostelium discoideum.
@en
P2093
J A Cardelli
R C Mierendorf
R L Dimond
P2860
P304
P356
10.1083/JCB.100.5.1777
P407
P577
1985-05-01T00:00:00Z