Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization
about
An SH2-domain-containing kinase negatively regulates the phosphatidylinositol-3 kinase pathwayPhosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclaseAttenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid.A plasma membrane template for macropinocytic cups.RacF1, a novel member of the Rho protein family in Dictyostelium discoideum, associates transiently with cell contact areas, macropinosomes, and phagosomes.Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole.Dictyostelium discoideum as a model system for identification of Burkholderia pseudomallei virulence factors.Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in DictyosteliumSequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in DictyosteliumEstablishing direction during chemotaxis in eukaryotic cellsPhagocytosis and macropinocytosis in Dictyostelium: phosphoinositide-based processes, biochemically distinct.Inactivation of lmpA, encoding a LIMPII-related endosomal protein, suppresses the internalization and endosomal trafficking defects in profilin-null mutants.Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.Fusion and fission events in the endocytic pathway of Dictyostelium.Genetic control of morphogenesis in Dictyostelium.Identification of a suppressor of the Dictyostelium profilin-minus phenotype as a CD36/LIMP-II homologueThe small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum.Overexpression of a novel rho family GTPase, RacC, induces unusual actin-based structures and positively affects phagocytosis in Dictyostelium discoideumRole of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells.Two distinct functions for PI3-kinases in macropinocytosisIdentification of protein kinase B (PKB) as a phosphatidylinositol 3,4,5-trisphosphate binding protein in Dictyostelium discoideum.Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis.Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae sec14p are found in the same cell.PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis.Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium.Role of phosphatidylinositol 3' kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium.Endocytosis and vesicular trafficking of immune complexes and activation of phospholipase D by the human high-affinity IgG receptor requires distinct phosphoinositide 3-kinase activities.Characterization of CD36/LIMPII homologues in Dictyostelium discoideum.A diverse family of inositol 5-phosphatases playing a role in growth and development in Dictyostelium discoideum.The physiological regulation of macropinocytosis during Dictyostelium growth and development.Amplification of PIP3 signalling by macropinocytic cups.Drink or drive: competition between macropinocytosis and cell migration.
P2860
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P2860
Inactivation of two Dictyostelium discoideum genes, DdPIK1 and DdPIK2, encoding proteins related to mammalian phosphatidylinositide 3-kinases, results in defects in endocytosis, lysosome to postlysosome transport, and actin cytoskeleton organization
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Inactivation of two Dictyostel ...... ctin cytoskeleton organization
@ast
Inactivation of two Dictyostel ...... ctin cytoskeleton organization
@en
type
label
Inactivation of two Dictyostel ...... ctin cytoskeleton organization
@ast
Inactivation of two Dictyostel ...... ctin cytoskeleton organization
@en
prefLabel
Inactivation of two Dictyostel ...... ctin cytoskeleton organization
@ast
Inactivation of two Dictyostel ...... ctin cytoskeleton organization
@en
P2093
P2860
P356
P1476
Inactivation of two Dictyostel ...... ctin cytoskeleton organization
@en
P2093
G Buczynski
J Cardelli
R A Firtel
P2860
P304
P356
10.1083/JCB.136.6.1271
P407
P577
1997-03-01T00:00:00Z