Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.
about
The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipinStable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity.Somatic mutagenesis in autoimmunityPotential serum and urine biomarkers in patients with lupus nephritis and the unsolved problemsThe role of somatic mutation in determining the affinity of anti-DNA antibodies.Specific recognition of a dsDNA sequence motif by an immunoglobulin VH homodimer.B cells in autoimmune diseases: insights from analyses of immunoglobulin variable (Ig V) gene usage.Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosusComplement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.Pathogenic and Epiphenomenal Anti-DNA Antibodies in SLE.Systematic analysis of sequences of anti-DNA antibodies--relevance to theories of origin and pathogenicity.Molecular expression systems for anti-DNA antibodies--1.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.An entity evolving into a community: defining the common ancestor and evolutionary trajectory of chronic lymphocytic leukemia stereotyped subset #4.Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.Activation-induced deaminase contributes to the antibody-independent role of B cells in the development of autoimmunity.Molecular mechanisms of autoimmunity.Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longitudinal immunogenetic evidence.Nature and functions of autoantibodies.Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes.Ongoing immunoglobulin class switch DNA recombination in lupus B cells: analysis of switch regulatory regions.B Cell Anergy Modulated by TLR1/2 and the miR-17∼92 Cluster Underlies the Indolent Clinical Course of Chronic Lymphocytic Leukemia Stereotyped Subset #4.Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection.Antibody Epitope Specificity for dsDNA Phosphate Backbone Is an Intrinsic Property of the Heavy Chain Variable Germline Gene Segment Used
P2860
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P2860
Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Structure-function analysis of ...... uble- and single-stranded DNA.
@ast
Structure-function analysis of ...... uble- and single-stranded DNA.
@en
type
label
Structure-function analysis of ...... uble- and single-stranded DNA.
@ast
Structure-function analysis of ...... uble- and single-stranded DNA.
@en
prefLabel
Structure-function analysis of ...... uble- and single-stranded DNA.
@ast
Structure-function analysis of ...... uble- and single-stranded DNA.
@en
P2093
P2860
P1476
Structure-function analysis of ...... uble- and single-stranded DNA.
@en
P2093
P2860
P304
P356
10.1002/1521-4141(200007)30:7<2015::AID-IMMU2015>3.0.CO;2-5
P407
P577
2000-07-01T00:00:00Z